Abstract
Hyperventilation syndrome (HVS) is a common source of dyspnea and disability. While pulmonary rehabilitation (PR) including breathing exercises is indicated, randomized controlled trial are warranted to recommend one type of breathing exercise than another. We aimed to compare during PR, the effect of 5 sessions of nasal ventilation exercise (NV+PR) versus voluntary hypoventilation (vHV+PR) on exercise dyspnea (primary outcome) and capacity and health-related quality of life in patients. In this open label randomized controlled trial, 19 HVS patients (age=48.3 ± 15.2 y.o, female/male=18/1, Nijmegen score=33 ± 7.7) were randomized in a NV+PR (n=9) or vHV+PR (n=10) group. Modified Medical Research Council (mMRC) dyspnea, 6-minute walking distance (6MWD) with nasal/oral ventilation were assessed before and after 3 months of PR, and questionnaires (Nijmegen, VQ-11). There was a significant effect of PR of but no significant difference between groups in the improvements of dyspnea@max exercise (time effect (T): p<0.01; group (G): p=0.63; group*time interaction (G*T): p=0.49), mMRC dyspnea (T: p<0.01; G: p=0.45; G*T: p=0.62), 6MWD (T: p<0.05; G: p=0.36; G*T: p=0.31), VQ-11 (T: p<0.001; G: p=0.16; G*T: p=0.09) and plasma HCO3- (T: p<0.05; G: p=0.93; G*T; p=0.36), Yet, Nijmegen score (T: p<0.01; G: p=0.32; G*T: p<0.05) improvement was larger in NV+PR group. The exercise oronasal breathing shift during the 6MWT was significantly delayed in all patients (T: p<0.05; G: p=0.30; G*T: p=0.32) and positively correlated with plasma HCO3-(r=0.42; p<0.05). Nasal exercise was not superior versus voluntary hypoventilation during PR in HVS patients. Yet, nasal exercise appeared feasible, leading to acquisition of a nasal breathing pattern during walking, improvement of PR outcomes and ventilatory alkalosis. The link between nasal breathing and hyperventilation is discussed in the light of the nasal ventilation rhythm in the limbic system and its role on the limbic emotional and ventilatory functions.