Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame

Tharwat Mohy El-Dine; Matthieu Lavayssiere; Hélène Adihou; Gilles Subra; Thomas-Xavier Métro; Olivier Ludemann-Hombourger; Frédéric Lamaty

doi:10.26434/chemrxiv-2023-2hhhk

Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame

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Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame

Tharwat Mohy El-Dine, Matthieu Lavayssiere, Hélène Adihou, Gilles Subra, Thomas-Xavier Métro, Olivier Ludemann-Hombourger and Frédéric Lamaty

DOI: https://doi.org/10.26434/chemrxiv-2023-2hhhk

Abstract

The solventless synthesis of peptides from unactivated amino acids was performed in a twin-screw extruder. The general method was applied to the preparation of dipeptides and tripeptides. Aspartame, a synthetic dipeptide, was also prepared in a continuous mode on large scale.

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Title: Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame
Creators - without role: Tharwat Mohy El-Dine - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Matthieu Lavayssiere - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Hélène Adihou - PolyPeptide Group
Gilles Subra - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Thomas-Xavier Métro - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Olivier Ludemann-Hombourger - PolyPeptide Group
Frédéric Lamaty - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Identifiers: 9946021209311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Working paper
Local Fields: hal-04361336