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Global stability in an age-structured SIRS malaria transmission model
Document de travail   Open Access

Global stability in an age-structured SIRS malaria transmission model

Seraphin Djaoue, Quentin Richard, Antoine Perasso et Irépran Damakoa

Résumé

Malaria Age-structured model Global stability Integrated semigroups Malaria Age-structured model Global stability Integrated semigroups
This paper proposes and analyzes a malaria transmission model structured by the chronological age of the human host population. The model couples an age-structured SIRS system for humans, incorporating waning immunity, with an SI system for mosquitoes under mass-action transmissions. Using integrated semigroup theory and spectral analysis, we establish the well-posedness of the model, derive the basic reproduction number, and prove the global asymptotic stability of the parasite-free equilibrium by using a Lyapunov functional, when $R_0\leq 1$, thereby excluding the possibility of backward bifurcation. Numerical simulations further suggest the global stability of the endemic equilibrium when $R_0>1$.

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