Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

Lucía de Hoyos; Fenja Schlag; Sanjeevan Jahagirdar; Elizabeth C Corfield; Andrea G Allegrini; Danielle a G Admiraal; Eveline L de Zeeuw; Ilja M Nolte; Natalia Llonga; Alexander Neumann; Katherine Lange; Simone van den Bedem; Ebba Du Rietz; Ehsan Motazedi; Else Eising; Nicole y T Ng; Teemu Palviainen; Carol A Wang; Elisabeth Thiering; Sofia Scatolin; Priyanka Choudhary; Natalia Vilor-Tejedor; Zhijie Liao; Silvia Alemany; Casper-Emil T Pedersen; Nora Fernandez-Jimenez; Megan L Campbell; Polina Girchenko; Eli Barthome; Hanna Seelemeyer; Afsheen Kumar; Alexandre Jeanne; Tarunveer S Ahluwalia; Melissa H Black; Jan K Buitelaar; Simon E Fisher; Anni Heiskala; María Hernández-Lorca; Vincent W Jaddoe; Marjo-Riitta Järvelin; Sheri-Michelle Koopowitz; Marilyn T Lake; Paul Lichtenstein; Sabrina Llop; Mannan Luo; Anni Malmberg; Sergi Marí; Albertine J Oldehinkel; Zdenka Pausova; Craig E Pennell; Robert Plomin; Ted Reichborn-Kjennerud; Sheena Reilly; Alina Rodriguez; Thomas Rolland; Angelica Ronald; Katri Räikkönen; Jean Shin; María Soler Artigas; Ashley E Tate; Henning Tiemeier; Ellen Verhoef; Eero Vuoksimaa; Melissa Wake; Varun Warrier; Eivind Ystrom; Sven Bölte; Christine Ecker; Thomas Bourgeron; Jari Lahti; Dan J Stein; Jose Ramon Bilbao; Klaus Bønnelykke; Mariona Bustamante; Tomas Paus; Christel M Middeldorp; Jordi Sunyer; Sylvain Sebert; Marie Standl; Andrew J O Whitehouse; Jaakko Kaprio; J Antoni Ramos-Quiroga; Marta Ribases; Miguel Casas; Rosa Bosch; Angela T Morgan; Tanja G M Vrijkotte; Henrik Larsson; Charlotte a M Cecil; Catharina A Hartman; Dorret I Boomsma; Kaili Rimfeld; Alexandra Havdahl; Beate St Pourcain

doi:10.1101/2025.08.16.667148

Retour

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

Document de travail

Open Access

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

Lucía de Hoyos, Fenja Schlag, Sanjeevan Jahagirdar, Elizabeth C Corfield, Andrea G Allegrini, Danielle a G Admiraal, Eveline L de Zeeuw, Ilja M Nolte, Natalia Llonga, Alexander Neumann, …

17/08/2025

DOI: https://doi.org/10.1101/2025.08.16.667148

Résumé

Social behaviour is a heritable, context-dependent trait that changes across social settings and development, influencing wellbeing and mental health. We present the first genome-wide metaregression study of social behaviour from infancy to early adulthood, leveraging 491,246 repeat measures of low prosocial behaviour and peer/social difficulties in European-ancestry cohorts (Neff=121,777, Nind=73,321). We modelled heterogeneity in genetic effects across social domains, informants, and ages (2–29 years), capturing social context through genomic influences. Six loci were identified, including variation within CADM2 (p=2.51x10-9). The SNP-based heritability was modest (2–7%), and the genetic architecture of social behaviour multidimensional. Polygenic scores demonstrated predictability and accuracy in independent European-ancestry cohorts and, partially, in African-ancestry cohorts (Nind=16,305). Genetic correlations with later-life and mental health outcomes showed context-dependent patterns. Modelling predicted onsets of associations with social behaviour revealed distinct profiles, as observed for autism, ADHD, depression and schizophrenia, highlighting novel opportunities to genetically proxy developmental trajectories.

Fichiers et liens (1)

url

Find in HALAfficher

Indicateurs

1 Consultations de la notice

See more details

Détails

Titre: Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages
Créateurs - sans rôle: Lucía de Hoyos - Max Planck Institute for Psycholinguistics
Fenja Schlag - Max Planck Institute for Psycholinguistics
Sanjeevan Jahagirdar - Max Planck Institute for Psycholinguistics
Elizabeth C Corfield - University of Bristol
Andrea G Allegrini - King's College London
Danielle a G Admiraal - Max Planck Institute for Psycholinguistics
Eveline L de Zeeuw - Vrije Universiteit Amsterdam
Ilja M Nolte - University of Groningen
Natalia Llonga - Centre for Biomedical Network Research on Rare Diseases
Alexander Neumann - Erasmus MC
Katherine Lange - Murdoch Children's Research Institute
Simone van den Bedem - Max Planck Institute for Psycholinguistics
Ebba Du Rietz - Karolinska Institutet
Ehsan Motazedi - Amsterdam University Medical Centers
Else Eising - Max Planck Institute for Psycholinguistics
Nicole y T Ng - Max Planck Institute for Psycholinguistics
Teemu Palviainen - Institute for Molecular Medicine Finland
Carol A Wang - Hunter Medical Research Institute
Elisabeth Thiering - Helmholtz Zentrum München
Sofia Scatolin - University of Zurich
Priyanka Choudhary - University of Oulu
Natalia Vilor-Tejedor - Barcelona Institute of Science and Technology
Zhijie Liao - Centre Hospitalier Universitaire Sainte-Justine
Silvia Alemany - Barcelona Institute for Global Health
Casper-Emil T Pedersen - University of Copenhagen
Nora Fernandez-Jimenez - BioCruces Health research Institute
Megan L Campbell - South African Medical Research Council
Polina Girchenko - University of Helsinki
Eli Barthome - Centre National de la Recherche Scientifique
Hanna Seelemeyer - Goethe University Frankfurt
Afsheen Kumar - Goethe University Frankfurt
Alexandre Jeanne - Goethe University Frankfurt
Tarunveer S Ahluwalia - University of Copenhagen
Melissa H Black - Curtin University
Jan K Buitelaar - Karakter
Simon E Fisher - Max Planck Institute for Psycholinguistics
Anni Heiskala - University of Oulu
María Hernández-Lorca - Copenhagen Prospective Studies on Asthma in Childhood
Vincent W Jaddoe - Erasmus MC
Marjo-Riitta Järvelin - Imperial College London
Sheri-Michelle Koopowitz - University of Cape Town
Marilyn T Lake - South African Medical Research Council
Paul Lichtenstein - Karolinska Institutet
Sabrina Llop - Universitat de València
Mannan Luo - Erasmus MC
Anni Malmberg - University of Helsinki
Sergi Marí - BioCruces Health research Institute
Albertine J Oldehinkel - University Medical Center Groningen
Zdenka Pausova - Centre Hospitalier Universitaire Sainte-Justine
Craig E Pennell - Hunter Medical Research Institute
Robert Plomin - King's College London
Ted Reichborn-Kjennerud - Center for Child and Adolescent Mental Health, Eastern and Southern Norway
Sheena Reilly - Griffith University
Alina Rodriguez - Anglia Ruskin University
Thomas Rolland - Centre National de la Recherche Scientifique
Angelica Ronald - University of Surrey
Katri Räikkönen - University of Helsinki
Jean Shin - Centre Hospitalier Universitaire Sainte-Justine
María Soler Artigas - Centre for Biomedical Network Research on Rare Diseases
Ashley E Tate - Karolinska Institutet
Henning Tiemeier - Erasmus MC
Ellen Verhoef - Max Planck Institute for Psycholinguistics
Eero Vuoksimaa - Institute for Molecular Medicine Finland
Melissa Wake - Murdoch Children's Research Institute
Varun Warrier - University of Cambridge
Eivind Ystrom - Norwegian Institute of Public Health
Sven Bölte - Curtin University
Christine Ecker - Goethe University Frankfurt
Thomas Bourgeron - Centre National de la Recherche Scientifique
Jari Lahti - University of Helsinki
Dan J Stein - South African Medical Research Council
Jose Ramon Bilbao - University of the Basque Country
Klaus Bønnelykke - University of Copenhagen
Mariona Bustamante - Barcelona Institute for Global Health
Tomas Paus - Centre Hospitalier Universitaire Sainte-Justine
Christel M Middeldorp - Children’s Health Queensland Hospital and Health Service
Jordi Sunyer - Hospital del Mar Research Institute
Sylvain Sebert - University of Oulu
Marie Standl - German Center for Pediatric and Adolescent Rheumatology
Andrew J O Whitehouse - The University of Western Australia
Jaakko Kaprio - Institute for Molecular Medicine Finland
J Antoni Ramos-Quiroga - Centre for Biomedical Network Research on Rare Diseases
Marta Ribases - Centro de Investigación Biomédica en Red de Salud Mental
Miguel Casas - Institut de Recerca Sant Joan de Déu
Rosa Bosch - Institut de Recerca Sant Joan de Déu
Angela T Morgan - Murdoch Children's Research Institute
Tanja G M Vrijkotte - Amsterdam University Medical Centers
Henrik Larsson - Karolinska Institutet
Charlotte a M Cecil - Erasmus MC
Catharina A Hartman - University Medical Center Groningen
Dorret I Boomsma - Vrije Universiteit Amsterdam
Kaili Rimfeld - King's College London
Alexandra Havdahl - Lovisenberg Diakonale Høgskole
Beate St Pourcain - Max Planck Institute for Psycholinguistics
Note de subvention: L.d.H., F.S., D.A.G.A., S.J., E. Verhoef, S.v.d.B., S. Scatolin, E.E., N.Y.T.N., S.E.F., and B.S.P. were supported by the Max Planck Society. S.J., A.K., A.J., E.B., H.S., M.H.B., T.R., C.E., S.B., T.B., and B.S.P. were supported by the R2D2-MH, which has been funded by Horizon Europe (grant agreement no. 101057385), by UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee [grant no. 10039383] and by the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number 22.00277. B.S.P. is also supported by the Radboud University Donders RSF 2025. T.G.M.V. was supported by ZonMW (TOP 40–00812–98–11010). C.A.M.C. is supported by the Horizon Europe Research and Innovation Programme (FAMILY, grant agreement no. 101057529, also to A.N.; HappyMums, grant agreement no. 101057390) and the European Research Council (TEMPO; grant agreement no. 101039672, also to A.N.). A.N. and H.T. are supported by a grant from the Dutch Ministry of Education, Culture, and Science and the Netherlands Organisation for Scientific Research (NWO grant no. 024.001.003, Consortium on Individual Development). The work of H.T. is further supported by the European Union’s Horizon 2020 research and innovation program (Contract grant no. 633595, DynaHealth) and an NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). M.L. was supported by the scholarship from the China Scholarship Council (201706990036). This work of M.L. was further supported by the Ter Meulen Grant of the Royal Netherlands Academy of Arts and Sciences (KNAW). J.L. has received research support from the Strategic Research Council (SRC) established within the Academy of Finland (decision no. 352700). S.A. acknowledges her Miguel Servet contract (CP22/00026) awarded by the Instituto de Salud Carlos III and co-funded by the European Union Fund (Fondo Social Europeo Plus, FSE+). A. Havdahl was supported by funding from the Research Council of Norway (RCN) (#274611, #336085) and the South-Eastern Norway Regional Health Authority (HSØ) (#2020022 & #2018059). E.C.C. was supported by funding from the RCN (#274611) and HSØ (#2021045) and is a member of the MRC Integrative Epidemiology Unit at the University of Bristol which is supported by the Medical Research Council and the University of Bristol (MC_UU_00032/1). T.R-K. was supported by funding from the RCN (#274611). E.Y. was supported by funding from the RCN (#288083 and #336078) and the European Union (Grant agreement No. 101045526 and No. 818425). P.C. has received funding from the University of Oulu and the Academy of Finland Profi6 (decision number AF 336449). S. Sebert acknowledges funding support by The Horizon Europe framework programme (STAGE [Grant N° 101137146]; IHEN [Grant N°101137317], OBELISK Grant [N° 101080465], OBCT Grant N°[101080250], TRIGGER [Grant N°101057739]), The Horizon 2020 framework programme (LongITools [Grant N°874739], EarlyCause [Grant N°848158]) and the research council of Finland [Grant N°356888]. M-R.J. acknowledges funding support by The Horizon 2020 framework programme (LongITools [Grant N°874739], EarlyCause [Grant N°848158]) and by the MRC Centre for Environment and Health funded by the Medical Research Council, UK (MR/S019669/1). D.I.B. acknowledges the Royal Netherlands Academy of Science Professor Award (PAH/6635). A. Ronald received funding from the Simons Foundation (Award ID: 724306). K. Rimfeld is supported by a Sir Henry Wellcome Postdoctoral Fellowship (213514/Z/18/Z). N.V-T. is supported by the Spanish Ministry of Science and Innovation - State Research Agency grant RYC2022-038136-I, cofunded by the European Union FSE+, and grant PID2022-143106OA-I00, cofunded by the European Union FEDER. Additionally, N.V-T. is supported by the William H. Gates Sr. Fellowship from the Alzheimer’s Disease Data Initiative. TEDS is supported by a programme Grant to R.P. from the UK Medical Research Council (Grant Nos. MR/V012878/1 and previously MR/M021475/1), with additional support from the US National Institutes of Health (Grant No. AG046938). The research leading to these results has also received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ grant agreement n° 602768. V.W. is supported by funding from the Simons Foundation for Autism Research Initiative, the Wellcome Trust (214322\Z\18\Z), Horizon-Europe R2D2-MH (grant agreement number 101057385), and UKRI (10063472). J.K.B. has been supported by the EU-AIMS (European Autism Interventions) and AIMS-2-TRIALS programmes which receive support from Innovative Medicines Initiative Joint Undertaking Grant No. 115300 and 777394, the resources of which are composed of financial contributions from the European Union’s FP7 and Horizon2020 Programmes, and from the European Federation of Pharmaceutical Industries and Associations (EFPIA) companies’ in-kind contributions, and AUTISM SPEAKS, Autistica and SFARI; and by the Horizon2020 supported programme CANDY Grant No. 847818).
Identifiants: 99137490109311
Unité académique: Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Langue: English
Type de ressource: Working paper
Champs locaux: pasteur-05343493