Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium

Laura S van Velzen; Lejla Colic; Zuriel Ceja; Maria R Dauvermann; Luca M Villa; Hannah S Savage; Yara J Toenders; Niousha Dehestani; Alyssa H Zhu; Adrian I Campos; Lauren E Salminen; Ingrid Agartz; Nina Alexander; Rosa Ayesa-Arriola; Elizabeth D Ballard; Nerisa Banaj; Carlotta Barkhau; Zeynep Başgöze; Jochen Bauer; Francesco Benedetti; Klaus Berger; Bianca Besteher; Katharina Brosch; Manuel Canal-Rivero; Simon Cervenka; Romain Colle; Colm G Connolly; Emmanuelle Corruble; Philippe Courtet; Baptiste Couvy-Duchesne; Benedicto Crespo-Facorro; Kathryn R Cullen; Udo Dannlowski; Jeremy Deverdun; Ana M Diaz-Zuluaga; Lorielle M.F. Dietze; Jennifer W Evans; Negar Fani; Kira Flinkenflügel; Naomi P Friedman; Ian H Gotlib; Nynke A Groenewold; Dominik Grotegerd; Tomas Hajek; Alexander S Hatoum; Marco Hermesdorf; Ian B Hickie; Yoshiyuki Hirano; Tiffany C Ho; Yuki Ikemizu; Frank Iorfino; Jonathan C Ipser; Yuko Isobe; Andrea P Jackowski; Fabrice Jollant; Tilo Kircher; Melissa Klug; Sheri-Michelle Koopowitz; Anna Kraus; Axel Krug; Emmanuelle Le Bars; Elisabeth J Leehr; Meng Li; Elizabeth T.C. Lippard; Carlos Lopez-Jaramillo; Ivan I Maximov; Andrew M Mcintosh; Katie A Mclaughlin; Sean R Mcwhinney; Susanne Meinert; Elisa Melloni; Philip B Mitchell; Benson Mwangi; Igor Nenadić; Stener Nerland; Emilie Olie; Victor Ortiz-García de la Foz; Pedro M Pan; F. Pereira; Fabrizio Piras; Federica Piras; Sara Poletti; Andrew E Reineberg; Gloria Roberts; Rafael Romero-García; Matthew D Sacchet; Giovanni A Salum; Anca-Larisa Sandu; Carl M Sellgren; Eiji Shimizu; Harry R Smolker; Jair C Soares; Gianfranco Spalletta; J. Douglas Steele; Frederike Stein; Dan J Stein; Benjamin Straube; Lea Teutenberg; Florian Thomas-Odenthal; Paula Usemann; Romain Valabregue; Johanna Valencia-Echeverry; Gerd Wagner; Gordon Waiter; Martin Walter; Heather C Whalley; Mon-Ju Wu; Tony T Yang; Carlos A Zarate; Andre Zugman; Giovana B Zunta-Soares; Kees van Heeringen; Sanne J.H. van Rooij; Nic van der Wee; Steven van der Werff; Paul M Thompson; Hilary P Blumberg; Anne-Laura van Harmelen; Miguel E Rentería; Neda Jahanshad; Lianne Schmaal

doi:10.1101/2024.11.07.24316876

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Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium

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Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium

Laura S van Velzen, Lejla Colic, Zuriel Ceja, Maria R Dauvermann, Luca M Villa, Hannah S Savage, Yara J Toenders, Niousha Dehestani, Alyssa H Zhu, Adrian I Campos, …

07/11/2024

DOI: https://doi.org/10.1101/2024.11.07.24316876

PMCID: PMC11722476

PMID: 39802789

Abstract

Abstract Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy, axial diffusivity, mean diffusivity and radial diffusivity) for 25 WM tracts were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of suicide attempt ( n =652; mean age=35.4±14.7; female=71.8%), individuals with a psychiatric diagnosis but no STB (i.e., clinical controls; n =1871; mean age=34±14.8; female=59.8%), and individuals with no mental disorder diagnosis and no STB (i.e., healthy controls; n =642; mean age=29.6±13.1; female=62.9%). We also compared these measures among individuals with recent suicidal ideation ( n =714; mean age=36.3±15.3; female=66.1%), clinical controls ( n =1184; mean age=36.8±15.6; female=63.1%), and healthy controls ( n =1240; mean age= 31.6±15.5; female=61.0%). We found subtle but statistically significant effects, such as lower fractional anisotropy associated with a history of suicide attempt, over and above the effect of psychiatric diagnoses. These effects were strongest in the corona radiata, thalamic radiation, fornix/stria terminalis, corpus callosum and superior longitudinal fasciculus. Effect sizes were small (Cohen’s d < 0.25). Recent suicidal ideation was not associated with alterations in WM microstructure. This large-scale coordinated mega-analysis revealed subtle regional and global alterations in WM microstructure in individuals with a history of suicide attempt. Longitudinal studies are needed to confirm whether these alterations are a risk factor for suicidal behaviour.

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Title: Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
Creators - without role: Laura S van Velzen - Orygen
Lejla Colic - Jena University Hospital
Zuriel Ceja - University of Queensland
Maria R Dauvermann - University of Birmingham
Luca M Villa - Yale University
Hannah S Savage - University of Melbourne
Yara J Toenders - Erasmus University Rotterdam
Niousha Dehestani - Deakin University
Alyssa H Zhu - University of Southern California
Adrian I Campos - Regeneron
Lauren E Salminen - University of Southern California
Ingrid Agartz - Diakonhjemmet Hospital
Nina Alexander - Philipps University of Marburg
Rosa Ayesa-Arriola - Marqués de Valdecilla University Hospital
Elizabeth D Ballard - National Institutes of Health
Nerisa Banaj - Fondazione Santa Lucia
Carlotta Barkhau - University of Münster
Zeynep Başgöze - University of Minnesota Medical Center
Jochen Bauer - University Hospital Münster
Francesco Benedetti - Vita-Salute San Raffaele University
Klaus Berger - University of Münster
Bianca Besteher - Jena University Hospital
Katharina Brosch - Feinstein Institute for Medical Research
Manuel Canal-Rivero - Hospital Universitario Virgen del Rocío
Simon Cervenka - Karolinska Institutet
Romain Colle - Inserm
Colm G Connolly - Florida State University
Emmanuelle Corruble - Centre de recherche en Epidémiologie et Santé des Populations
Philippe Courtet - Université de Montpellier
Baptiste Couvy-Duchesne - Centre National de la Recherche Scientifique
Benedicto Crespo-Facorro - Centro de Investigación Biomédica en Red de Salud Mental
Kathryn R Cullen - University of Minnesota Medical Center
Udo Dannlowski - University of Münster
Jeremy Deverdun - Hôpital Gui de Chauliac
Ana M Diaz-Zuluaga - University of California, Los Angeles
Lorielle M.F. Dietze - Dalhousie University
Jennifer W Evans - National Institute of Mental Health
Negar Fani - Emory University
Kira Flinkenflügel - University of Münster
Naomi P Friedman - University of Colorado Boulder
Ian H Gotlib - Stanford University
Nynke A Groenewold - University of Cape Town
Dominik Grotegerd - University of Münster
Tomas Hajek - Dalhousie University
Alexander S Hatoum - Washington University in St. Louis
Marco Hermesdorf - University of Münster
Ian B Hickie - University of Sydney
Yoshiyuki Hirano - Hamamatsu University
Tiffany C Ho - University of California, Los Angeles
Yuki Ikemizu - Chiba University
Frank Iorfino - University of Sydney
Jonathan C Ipser - University of Cape Town
Yuko Isobe - Hamamatsu University
Andrea P Jackowski - Østfold University College
Fabrice Jollant - Centre Hospitalier Universitaire de Nîmes
Tilo Kircher - Philipps University of Marburg
Melissa Klug - University of Münster
Sheri-Michelle Koopowitz
Anna Kraus - University of Münster
Axel Krug - University Hospital Bonn
Emmanuelle Le Bars
Elisabeth J Leehr - University of Münster
Meng Li - Jena University Hospital
Elizabeth T.C. Lippard
Carlos Lopez-Jaramillo - Universidad de Antioquia
Ivan I Maximov
Andrew M Mcintosh - University of Edinburgh
Katie A Mclaughlin - Harvard University
Sean R Mcwhinney - Dalhousie University
Susanne Meinert - University of Münster
Elisa Melloni - Vita-Salute San Raffaele University
Philip B Mitchell - UNSW Sydney
Benson Mwangi - The University of Texas Health Science Center at Houston
Igor Nenadić - Philipps University of Marburg
Stener Nerland - University of Oslo
Emilie Olie - Université de Montpellier
Victor Ortiz-García de la Foz
Pedro M Pan - Universidade Federal de São Paulo
F. Pereira - Université de Nîmes
Fabrizio Piras - Fondazione Santa Lucia
Federica Piras
Sara Poletti - Vita-Salute San Raffaele University
Andrew E Reineberg - University of Colorado Boulder
Gloria Roberts - UNSW Sydney
Rafael Romero-García - University of Cambridge
Matthew D Sacchet - Massachusetts General Hospital
Giovanni A Salum - Hospital de Clínicas de Porto Alegre
Anca-Larisa Sandu
Carl M Sellgren - Karolinska Institutet
Eiji Shimizu - Osaka University
Harry R Smolker - University of Colorado Boulder
Jair C Soares - The University of Texas Health Science Center at Houston
Gianfranco Spalletta - Baylor College of Medicine
J. Douglas Steele - University of Dundee
Frederike Stein - Philipps University of Marburg
Dan J Stein - University of Cape Town
Benjamin Straube - Philipps University of Marburg
Lea Teutenberg - Philipps University of Marburg
Florian Thomas-Odenthal - Philipps University of Marburg
Paula Usemann - Philipps University of Marburg
Romain Valabregue - Inserm
Johanna Valencia-Echeverry - Universidad de Antioquia
Gerd Wagner - Jena University Hospital
Gordon Waiter - University of Aberdeen
Martin Walter - Jena University Hospital
Heather C Whalley - University of Edinburgh
Mon-Ju Wu - The University of Texas Health Science Center at Houston
Tony T Yang - University of California, San Francisco
Carlos A Zarate - National Institute of Mental Health
Andre Zugman - National Institute of Mental Health
Giovana B Zunta-Soares - The University of Texas Health Science Center at Houston
Kees van Heeringen - Ghent University Hospital
Sanne J.H. van Rooij - Emory University
Nic van der Wee
Steven van der Werff - Leiden University Medical Center
Paul M Thompson - University of Southern California
Hilary P Blumberg - Yale University
Anne-Laura van Harmelen
Miguel E Rentería - QIMR Berghofer Medical Research Institute
Neda Jahanshad - University of Southern California
Lianne Schmaal - University of Melbourne
Identifiers: 9934404909311
Academic Unit: Institut de Génomique Fonctionnelle - IGF
Language: English
Resource Type: Preprint
Local Fields: hal-05075210