Genomic diversity of the African malaria vector Anopheles funestus

Marilou Boddé; Joachim Nwezeobi; Petra Korlević; Alex Makunin; Ousman Akone-Ella; Sonia Barasa; Mahamat Gadji; Lee Hart; Emmanuel W Kaindoa; Katie Love; Eric R Lucas; Ibra Lujumba; Mara Máquina; Sanjay Nagi; Joel O Odero; Brian Polo; Claire Sangbakembi; Samuel Dadzie; Lizette L Koekemoer; Dominic Kwiatkowski; Erica McAlister; Eric Ochomo; Fredros Okumu; Krijn Paaijmans; David P Tchouassi; Charles S Wondji; Diego Ayala; Richard Durbin; Alistair Miles; Mara K N Lawniczak

doi:10.1101/2024.12.14.628470

Prépublication

Genomic diversity of the African malaria vector Anopheles funestus

Marilou Boddé, Joachim Nwezeobi, Petra Korlević, Alex Makunin, Ousman Akone-Ella, Sonia Barasa, Mahamat Gadji, Lee Hart, Emmanuel W Kaindoa, Katie Love, …

bioRxiv

17/12/2024

DOI: https://doi.org/10.1101/2024.12.14.628470

PMID: 39763861

Résumé

s.s. is a formidable human malaria vector across sub-Saharan Africa. To understand how the species is evolving, especially in response to malaria vector control, we sequenced 656 modern specimens (collected 2014-2018) and 45 historic specimens (collected 1927-1967) from 16 African countries. We find high levels of genetic variation with clear and stable continental patterns. Six segregating inversions might be involved in adaptation of local ecotypes. Strong recent signals of selection centred on canonical insecticide resistance genes are shared by multiple populations. A promising gene drive target in is highly conserved in . This work represents a significant advance in our understanding of the genetic diversity and population structure of and will enable smarter targeted malaria control.

Indicateurs

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Détails

Titre: Genomic diversity of the African malaria vector Anopheles funestus
Créateurs - sans rôle: Marilou Boddé - Institut Pasteur, Antananarivo, Madagascar
Joachim Nwezeobi - Wellcome Sanger Institute
Petra Korlević - Wellcome Sanger Institute, Hinxton, United Kingdom
Alex Makunin - Wellcome Sanger Institute, Hinxton, United Kingdom
Ousman Akone-Ella - CIRMF, Franceville, Gabon
Sonia Barasa - Kenya Medical Research Institute, Kenya
Mahamat Gadji - Centre for Research In Infectious Disease, Yaounde, Cameroon
Lee Hart - Wellcome Sanger Institute, Hinxton, United Kingdom
Emmanuel W Kaindoa - Ifakara Health Institute
Katie Love - Wellcome Sanger Institute
Eric R Lucas - Liverpool School of Tropical Medicine, United Kingdom
Ibra Lujumba - Kenya Medical Research Institute, Kenya
Mara Máquina - Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique
Sanjay Nagi - Liverpool School of Tropical Medicine, United Kingdom
Joel O Odero - Ifakara Health Institute, Tanzania
Brian Polo - Kenya Medical Research Institute, Kenya
Claire Sangbakembi - Institut Pasteur de Bangui, Gabon
Samuel Dadzie - Noguchi Memorial Institute for Medical Research, Legon, Ghana
Lizette L Koekemoer - University of the Witwatersrand
Dominic Kwiatkowski - Wellcome Sanger Institute, Hinxton, United Kingdom
Erica McAlister - Museum of London
Eric Ochomo - Kenya Medical Research Institute, Kenya
Fredros Okumu - Ifakara Health Institute, Tanzania
Krijn Paaijmans - Arizona State University, Arizona, United States
David P Tchouassi - International Centre of Insect Physiology and Ecology
Charles S Wondji - Centre for Research In Infectious Disease, Yaounde, Cameroon
Diego Ayala - Institut Pasteur
Richard Durbin - University of Cambridge
Alistair Miles - Wellcome Sanger Institute
Mara K N Lawniczak - Wellcome Sanger Institute, Hinxton, United Kingdom
Détails de publication: bioRxiv
Éditeur: United States
Note de subvention: INV-008483 / Gates Foundation Wellcome Trust INV-024969 / Gates Foundation INV-001927 / Gates Foundation R01 AI116811 / NIAID NIH HHS
Identifiants: 99158959909311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Preprint