First imported Cases of MPXV Clade Ib in Goma, Democratic Republic of the Congo: Implications for Global Surveillance and Transmission Dynamics

Daniel Mukadi-Bamuleka; Eddy Kinganda-Lusamaki; Noella Mulopo-Mukanya; Adrienne Amuri-Aziza; Áine O’Toole; Brigitte Modadra-Madakpa; Guy Mutombo Ndongala; Emmanuel Hasivirwe Vakaniaki; Sydney Merritt; Cris Kacita; Gaston Lubambo Maboko; Jean-Claude Makangara-Cigolo; Michel Ngimba; Emmanuel Lokilo; Elisabeth Pukuta-Simbu; Gradi Luakanda; Tavia Bodisa-Matamu; Zephanie Paluku Kalimuli; Prince Akil-Bandali; Sifa Kavira; Daan Jansen; Adèle Kavira Kamaliro; Emile Muhindo-Milonde; Jeriel Mufungizi; Yves Birindwa Hamisi; Hugo Kavunga; Olivier Tshiani; Sabin S. Nundu; Laurens Liesenborghs; Nicole A. Hoff; Jean Nachega; Robert Shongo; Ahidjo Ayouba; Genay Pilarowski; Alain Kakule Mangolopa; Amos Kiuka Ebondo; Nicola Low; Souradet Y. Shaw; Sam Wilkinson; Sofonias Kifle Tessema; Lorenzo Subissi; Eric Delaporte; Koen Vercauteren; Tony Wawina-Bokalanga; Anne W Rimoin; Martine Peeters; Nicholas Loman; Andrew Rambaut; Jean-Jacques Muyembe-Tamfum; Lisa E. Hensley; Jason Kindrachuk; Placide Mbala-Kingebeni; Steve Ahuka-Mundeke

doi:10.1101/2024.09.12.24313188

Prépublication

First imported Cases of MPXV Clade Ib in Goma, Democratic Republic of the Congo: Implications for Global Surveillance and Transmission Dynamics

Daniel Mukadi-Bamuleka, Eddy Kinganda-Lusamaki, Noella Mulopo-Mukanya, Adrienne Amuri-Aziza, Áine O’Toole, Brigitte Modadra-Madakpa, Guy Mutombo Ndongala, Emmanuel Hasivirwe Vakaniaki, Sydney Merritt, Cris Kacita, …

medRxiv

Cold Spring Harbor Laboratory Press, 1.1

16/09/2024

DOI: https://doi.org/10.1101/2024.09.12.24313188

PMID: 39371169

Résumé

Infectious Diseases (except HIV/AIDS)

The ongoing national mpox outbreak in the Democratic Republic of the Congo has resulted in more >30,000 suspected cases in the country from January 2023 to August 2024. While these historic case totals have been driven by primarily by zoonosis, the emergence of Clade Ib monkeypox virus (MPXV), which is connected to more sustained human-to-human transmission, has been associated with increasing public health impacts in eastern DRC. First identified in South Kivu province, Clade Ib MPXV has been identified in multiple non-endemic East African countries for the first time. In DRC, there have been concerns over broader Clade Ib expansion in the country that could further complicate containment and mitigation responses. Here, we report the first introductions of Clade Ib into North Kivu province, including within internal displacement camps, with suspected close contact transmission that includes non-intimate contacts and children. These findings demonstrate that mpox case investigations and community messaging campaigns should include considerations for non-sexual contact-mediated transmission of Clade Ib that includes children <15 years.

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Détails

Titre: First imported Cases of MPXV Clade Ib in Goma, Democratic Republic of the Congo: Implications for Global Surveillance and Transmission Dynamics
Créateurs - sans rôle: Daniel Mukadi-Bamuleka - Rodolphe Merieux INRB-Goma Laboratory
Eddy Kinganda-Lusamaki - TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM)
Noella Mulopo-Mukanya - Rodolphe Merieux INRB-Goma Laboratory
Adrienne Amuri-Aziza - Institut National de Recherche Biomédicale (INRB)
Áine O’Toole - Institute of Ecology and Evolution, University of Edinburgh
Brigitte Modadra-Madakpa - Rodolphe Merieux INRB-Goma Laboratory
Guy Mutombo Ndongala - Provincial Health Division
Emmanuel Hasivirwe Vakaniaki - Institut National de Recherche Biomédicale (INRB)
Sydney Merritt - Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California
Cris Kacita - Hemorrhagic Fever and Monkeypox Program, Ministry of Health
Gaston Lubambo Maboko - Provincial Health Division
Jean-Claude Makangara-Cigolo - Institut National de Recherche Biomédicale (INRB)
Michel Ngimba - Rodolphe Merieux INRB-Goma Laboratory
Emmanuel Lokilo - Institut National de Recherche Biomédicale (INRB)
Elisabeth Pukuta-Simbu - Institut National de Recherche Biomédicale (INRB)
Gradi Luakanda - Institut National de Recherche Biomédicale (INRB)
Tavia Bodisa-Matamu - Rodolphe Merieux INRB-Goma Laboratory
Zephanie Paluku Kalimuli - Rodolphe Merieux INRB-Goma Laboratory
Prince Akil-Bandali - Institut National de Recherche Biomédicale (INRB)
Sifa Kavira - Institut National de Recherche Biomédicale (INRB)
Daan Jansen - Department of Clinical Sciences, Institute of Tropical Medicine
Adèle Kavira Kamaliro - Institut National de Recherche Biomédicale (INRB)
Emile Muhindo-Milonde - Institut National de Recherche Biomédicale (INRB)
Jeriel Mufungizi - Rodolphe Merieux INRB-Goma Laboratory
Yves Birindwa Hamisi - Rodolphe Merieux INRB-Goma Laboratory
Hugo Kavunga - Rodolphe Merieux INRB-Goma Laboratory
Olivier Tshiani - Institut National de Recherche Biomédicale (INRB)
Sabin S. Nundu - Institut National de Recherche Biomédicale (INRB)
Laurens Liesenborghs - Department of Clinical Sciences, Institute of Tropical Medicine
Nicole A. Hoff - Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California
Jean Nachega - University of Pittsburgh
Robert Shongo - Hemorrhagic Fever and Monkeypox Program, Ministry of Health
Ahidjo Ayouba - Université de Montpellier
Genay Pilarowski - Chan Zuckerberg Biohub
Alain Kakule Mangolopa - World Health Organization
Amos Kiuka Ebondo - World Health Organization
Nicola Low - University of Bern
Souradet Y. Shaw - Community Health Sciences, University of Manitoba
Sam Wilkinson - University of Birmingham
Sofonias Kifle Tessema - Africa Centres for Disease Control and Prevention
Lorenzo Subissi - World Health Organization
Eric Delaporte - Université de Montpellier
Koen Vercauteren - Department of Clinical Sciences, Institute of Tropical Medicine
Tony Wawina-Bokalanga - Department of Clinical Sciences, Institute of Tropical Medicine
Anne W Rimoin - Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California
Martine Peeters - Université de Montpellier
Nicholas Loman - University of Birmingham
Andrew Rambaut - TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM)
Jean-Jacques Muyembe-Tamfum - Institut National de Recherche Biomédicale (INRB)
Lisa E. Hensley - US Department of Agriculture, Agricultural Research Service
Jason Kindrachuk - University of Manitoba
Placide Mbala-Kingebeni - Institut National de Recherche Biomédicale (INRB)
Steve Ahuka-Mundeke - Institut National de Recherche Biomédicale (INRB)
Détails de publication: medRxiv
Éditeur: Cold Spring Harbor Laboratory Press
Édition: 1.1
Nombre de pages: 19
Identifiants: 99148780409311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Preprint