Résumé
In this paper, we present a simple yet sensitive method for glucose sensing
using carbon nanotube field-effect transistor (CNTFET) based biosensor. The
CNTs were well-dispersed to form CNT networks and maintain functional
connectivity among CNTs, which increases the electron transfer through the
network and thus, the electronic readout. Moreover, glucose oxidase (GOx)
molecules are immobilized by CNT functionalization to form effective and
sensitive CNT networks as FET channel. The CNTs are functionalized with linkers
(1-pyrenebutanoic acid succinimidyl ester) to immobilize GOx on CNTs, where GOx
serves as a mediator between CNTs and glucose for electron transfer. The liquid
analyte glucose is adsorbed on CNTs via GOx and linkers by releasing additional
electrons in the CNTFET channel and thus, increasing the CNTFET readout
current. The binding of the target glucose molecules and GOx emulates the gate
potential of FET channel and the electronic response of the sensor is recorded
in real-time. Moreover, the variations in electronic readout of CNTFET
biosensor are observed and is stipulated due to variation in CNT dispersion on
each device. Overall, this work presents a simple, fast, sensitive, low-cost,
and low concentration (0.01 mM) detection of glucose using CNTFET sensors.