Résumé
At early times the Universe was filled up with an extremely dense and hot gas. Due to the expansion it cooled below the binding energies of atoms which led to the formation of the first nuclei. In the physical environment of the post-recombination period of hydrogen, molecules such as$H_2$ ,$HD$and$LiH$can be formed. The proto-object formation, resulting from the growth of linear density fluctuations in the early Universe, can have an important impact on the chemical state of the Universe. Hence it can be enriched with metals, and thus lead to the formation of the first pre-biotic molecules. In this contribution, I will present some scheme for the formation of primordial molecules and discuss the consequence of the formation of first stars on the existence of possible primordial pre-biotic.