Résumé
Bortolotto
et al.
reply
— Nicoll
et al
. challenge our finding that kainate receptors are involved in mossy-fibre LTP in the hippocampus
1
. Their argument is based on a discrepancy of our results with earlier work, as we show (our Fig. 5)
1
that two kainate-receptor antagonists, kynurenate and CNQX, can also block mossy-fibre LTP. We do not dispute that it may be possible to induce mossy-fibre LTP in the presence of kainate-receptor antagonists under certain conditions. For this reason, we neither stated nor implied that activation of kainate receptors is always necessary for mossy-fibre LTP
1
.