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Xenopus tropicalis osteoblast-specific open chromatin regions reveal promoters and enhancers involved in human skeletal phenotypes and shed light on early vertebrate evolution
Journal article   Open access   Peer reviewed

Xenopus tropicalis osteoblast-specific open chromatin regions reveal promoters and enhancers involved in human skeletal phenotypes and shed light on early vertebrate evolution

Héctor Castillo, Patricia Hanna, Laurent Sachs, Nicolas Buisine, Francisco Godoy, Clément Gilbert, Felipe Aguilera, David Muñoz, Catherine Boisvert, Mélanie Debiais-Thibaud, …
Cells & Development, Vol.179
09/2024
DOI: https://doi.org/10.1016/j.cdev.2024.203924

Abstract

Xenopus tropicalis Osteoblasts ATAC-Seq Regulatory regions Bone diseases Skeletal Evolution
ATAC-seq identifies Xenopus tropicalis osteoblast-specific nucleosome-free regions.ChIP-seq and RNA-seq further validate 527 promoters and 6,747 enhancers.Twist, AP1, Tead, Runx2, Nfat, Nfi and Smad display TFBS enrichment. 425 conserved human regions are associated with skeletal phenotypes.Conservation with the elephant shark supports the homology of bone and dentine.
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