Viral factors in influenza pandemic risk assessment

Marc Lipsitch; Wendy Barclay; Rahul Raman; Charles J Russell; Jessica A Belser; Sarah Cobey; Peter M Kasson; James O Lloyd-Smith; Sebastian Maurer-Stroh; Steven Riley; Catherine Aa Beauchemin; Trevor Bedford; Thomas C Friedrich; Andreas Handel; Sander Herfst; Pablo R Murcia; Benjamin Roche; Claus O Wilke; Colin A Russell

doi:10.7554/eLife.18491

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Viral factors in influenza pandemic risk assessment

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Viral factors in influenza pandemic risk assessment

Marc Lipsitch, Wendy Barclay, Rahul Raman, Charles J Russell, Jessica A Belser, Sarah Cobey, Peter M Kasson, James O Lloyd-Smith, Sebastian Maurer-Stroh, Steven Riley, …

eLife, Vol.5(2016), e18491

11/11/2016

DOI: https://doi.org/10.7554/eLife.18491

PMID: 27834632

Résumé

Animals

Epidemiological Monitoring

Hemagglutinin Glycoproteins, Influenza Virus - genetics

Hemagglutinin Glycoproteins, Influenza Virus - metabolism

Humans

Influenza A virus - genetics

Influenza A virus - pathogenicity

Influenza, Human - epidemiology

Influenza, Human - virology

Pandemics

Risk Assessment

RNA-Dependent RNA Polymerase - genetics

RNA-Dependent RNA Polymerase - metabolism

Virulence Factors - genetics

Virulence Factors - metabolism

Zoonoses - epidemiology

Zoonoses - virology

The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures. We describe such efforts, identify progress and ongoing challenges, and discuss three specific traits of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency) that contribute to pandemic risk.

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Détails

Titre: Viral factors in influenza pandemic risk assessment
Créateurs - sans rôle: Marc Lipsitch - Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States
Wendy Barclay - Division of Infectious Disease, Faculty of Medicine, Imperial College, London, United Kingdom
Rahul Raman - Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, United States
Charles J Russell - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, United States
Jessica A Belser - Centers for Disease Control and Prevention, Atlanta, United States
Sarah Cobey - Department of Ecology and Evolutionary Biology, University of Chicago, Chicago, United States
Peter M Kasson - Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States
James O Lloyd-Smith - Fogarty International Center, National Institutes of Health, Bethesda, United States
Sebastian Maurer-Stroh - School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
Steven Riley - Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom
Catherine Aa Beauchemin - Department of Physics, Ryerson University, Toronto, Canada
Trevor Bedford - Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, United States
Thomas C Friedrich - Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, United States
Andreas Handel - Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, United States
Sander Herfst - Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands
Pablo R Murcia - MRC-University of Glasgow Centre For Virus Research, Glasgow, United Kingdom
Benjamin Roche - IRD/UPMC UMMISCO, Montpellier, France
Claus O Wilke - Department of Integrative Biology, The University of Texas at Austin, Austin, United States
Colin A Russell - Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
Détails de publication: eLife, Vol.5(2016), e18491
Note de subvention: Wellcome Trust R01 GM098304 / NIGMS NIH HHS 200187/Z/15/Z / Wellcome Trust MR/K010174/1 / Medical Research Council 200861/Z/16/Z / Wellcome Trust U19 AI117891 / NIAID NIH HHS R01 GM088344 / NIGMS NIH HHS 093488/Z/10/Z / Wellcome Trust K99 GM087550 / NIGMS NIH HHS G0801822 / Medical Research Council
Identifiants: 99158987309311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Journal article