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Vasoactive intestinal polypeptide and carbachol act synergistically to induce the hydrolysis of inositol containing phospholipids in the rat superior cervical ganglion
Article de revue   Avec comité de lecture

Vasoactive intestinal polypeptide and carbachol act synergistically to induce the hydrolysis of inositol containing phospholipids in the rat superior cervical ganglion

Thierry Durroux, Claude Barberis et Serge Jard
Neuroscience letters, Vol.75(2), pp.211-215
31/03/1987
PMID: 3574774

Résumé

Carbachol Inositol phosphate Rat Sympathetic ganglion Vasoactive intestinal polypeptide
The effects of vasoactive intestinal polypeptide (VIP) and carbachol on inositol lipid breakdown were assayed in isolated rat superior cervical ganglia. We report here that VIP and carbachol act synergistically to stimulate the formation of inositol phosphates. This synergistic interaction may explain the modulatory effect of VIP on the muscarinic transmission in the sympathetic ganglia.

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