Upfront surgery or definitive radiotherapy for p16+ oropharyngeal cancer. A GETTEC multicentric study

Dorian Culié; Renaud Schiappa; Anouchka Modesto; Julien Viotti; Emmanuel Chamorey; Olivier Dassonville; Gilles Poissonnet; Alain Bizeau; Sebastien Vergez; Agnes Dupret-Bories; Nicolas Fakhry; Laure Santini; Benjamin Lallemant; Guillaume Chambon; Anne Sudaka; Frederic Peyrade; Esma Saada-Bouzid; Karen Benezery; Florence Jourdan-Soulier; Françoise Chapel; Anne Sophie Ramay; Pascal Roger; Thibault Galissier; Valérie Coste; Aicha Ben Lakdar; Joanne Guerlain; Haitham Mirghani; Phillipe Gorphe; Bruno Guelfucci; Renaud Garrel; Stephane Temam; Alexandre Bozec

doi:10.1016/j.ejso.2020.12.011

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Upfront surgery or definitive radiotherapy for p16+ oropharyngeal cancer. A GETTEC multicentric study

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Upfront surgery or definitive radiotherapy for p16+ oropharyngeal cancer. A GETTEC multicentric study

Dorian Culié, Renaud Schiappa, Anouchka Modesto, Julien Viotti, Emmanuel Chamorey, Olivier Dassonville, Gilles Poissonnet, Alain Bizeau, Sebastien Vergez, Agnes Dupret-Bories, …

European journal of surgical oncology, Vol.47(6), pp.1389-1397

01/06/2021

DOI: https://doi.org/10.1016/j.ejso.2020.12.011

PMID: 33390333

Résumé

Cancer

Human papilloma virus

Oropharynx

Radiotherapy

Surgery

Survival

The aim of this study was to assess the impact of the initial therapeutic strategy on oncologic outcomes in patients with HPV-positive OPSCC. All p16-positive OPSCCs treated from 2009 to 2014 in 7 centers were retrospectively included and classified according to the therapeutic strategy: surgical strategy (surgery ± adjuvant radiotherapy and chemotherapy) vs. non-surgical strategy (definitive radiotherapy ± chemotherapy). Univariate, multivariate propensity score matching analyses were performed to compare overall (OS), disease-specific (DSS) and recurrence-free survival (RFS). 382 patients were included (surgical group: 144; non-surgical group: 238). Five-year OS, DSS and RFS were 89.2, 96.8 and 83.9% in the surgical group and 84.2, 87.1 and 70.4% in the non-surgical group, respectively. These differences were statistically significant for DSS and RFS after multivariate analysis, but only for RFS after propensity score matching analysis. In p16+ OPSCC patients, upfront surgery results in higher RFS than definitive radiotherapy ± chemotherapy but does not impact OS.

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Titre: Upfront surgery or definitive radiotherapy for p16+ oropharyngeal cancer. A GETTEC multicentric study
Créateurs - sans rôle: Dorian Culié - University Institute of the Face and Neck, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Renaud Schiappa - Department of Statistics, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Anouchka Modesto - Department of Radiotherapy, Cancer University Institute of Toulouse, Toulouse, France
Julien Viotti - Department of Statistics, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Emmanuel Chamorey - Department of Statistics, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Olivier Dassonville - University Institute of the Face and Neck, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Gilles Poissonnet - University Institute of the Face and Neck, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Alain Bizeau - Department of Otorhinolaryngology and Head and Neck Surgery, Sainte Musse Hospital, Toulon, France
Sebastien Vergez - Department of Otorhinolaryngology and Head and Neck Surgery, Cancer University Institute of Toulouse, Toulouse, France
Agnes Dupret-Bories - Department of Otorhinolaryngology and Head and Neck Surgery, Cancer University Institute of Toulouse, Toulouse, France
Nicolas Fakhry - Department of Otorhinolaryngology and Head and Neck Surgery, Public Assistance - Hospitals of Marseille, Marseille, France
Laure Santini - Department of Otorhinolaryngology and Head and Neck Surgery, Public Assistance - Hospitals of Marseille, Marseille, France
Benjamin Lallemant - Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France
Guillaume Chambon - Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France
Anne Sudaka - Department of Pathology, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Frederic Peyrade - Department of Medical Oncology, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Esma Saada-Bouzid - Department of Medical Oncology, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Karen Benezery - Department of Radiotherapy, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Florence Jourdan-Soulier - Department of Pathology, Sainte Musse Hospital, Toulon, France
Françoise Chapel - Department of Pathology, Sainte Musse Hospital, Toulon, France
Anne Sophie Ramay - Department of Pathology, University Hospital of Nîmes, Nîmes, France
Pascal Roger - Department of Pathology, University Hospital of Nîmes, Nîmes, France
Thibault Galissier - Department of Pathology, Cancer University Institute of Toulouse, Toulouse, France
Valérie Coste - Department of Pathology, University Hospital of Montpellier, Montpellier, France
Aicha Ben Lakdar - Department of Pathology, Gustave Roussy Institute, Villejuif, France
Joanne Guerlain - Department of Otorhinolaryngology and Head and Neck Surgery, Gustave Roussy Institute, Villejuif, France
Haitham Mirghani - Department of Otorhinolaryngology and Head and Neck Surgery, European Hospital Georges Pompidou, Paris, France
Phillipe Gorphe - Department of Otorhinolaryngology and Head and Neck Surgery, Gustave Roussy Institute, Villejuif, France
Bruno Guelfucci - Department of Otorhinolaryngology and Head and Neck Surgery, Sainte Musse Hospital, Toulon, France
Renaud Garrel - Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Montpellier, Montpellier, France
Stephane Temam - Department of Otorhinolaryngology and Head and Neck Surgery, Gustave Roussy Institute, Villejuif, France
Alexandre Bozec - University Institute of the Face and Neck, Antoine Lacassagne Centre, Côte D’Azur University, Nice, France
Détails de publication: European journal of surgical oncology, Vol.47(6), pp.1389-1397
Éditeur: Elsevier Ltd
Nombre de pages: 9
Identifiants: 99162825009311
Unité académique: Institut de Recherche en Cancérologie de Montpellier - IRCM; Recherche hors université
Langue: English
Type de ressource: Journal article