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Unveiling novel forms of hippocampal synaptic plasticity with microelectrode arrays.
Journal article   Peer reviewed

Unveiling novel forms of hippocampal synaptic plasticity with microelectrode arrays.

Fabien Lanté, Nadine Crouzin and Michel Vignes
Journal of Integrative Neuroscience, Vol.7(2), pp.249-70
06/2008
DOI: https://doi.org/10.1142/s0219635208001800
PMID: 18763723

Abstract

Age Factors Animals Neurons Patch-Clamp Techniques Animals, Newborn Rats Rats, Sprague-Dawley Sodium Channel Blockers Synapses Tetrodotoxin Brain Mapping Cyclic AMP Female Dose-Response Relationship, Radiation Electric Stimulation Enzyme Inhibitors Excitatory Amino Acid Agonists Excitatory Amino Acid Antagonists Hippocampus Male Membrane Potentials Microelectrodes Mitogen-Activated Protein Kinase Kinases Models, Neurological Neuronal Plasticity
In this report, we elucidate by use of microelectrode arrays novel forms of long-term depression and potentiation in the hippocampus which are triggered by low frequency afferent stimulation and which rely on the activation of metabotropic glutamate receptor of the fifth subtype (mGlu5 receptor).
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