Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

Josep M Antó; Mariona Pinart; Mübeccel Akdis; Charles Auffray; Claus Bachert; Xavier Basagaña; Kai-Håkon Carlsen; Stefano Guerra; Leena von Hertzen; Sabina Illi; Francine Kauffmann; Thomas Keil; James P Kiley; Gerard H Koppelman; Christian Lupinek; Fernando D Martinez; Martijn C Nawijn; Dirkje S Postma; Valérie Siroux; Henriette A Smit; Peter J Sterk; Jordi Sunyer; Rudolf Valenta; Sergio Valverde; Cezmi A Akdis; Isabella Annesi-Maesano; Ferran Ballester; Marta Benet; Anne Cambon-Thomsen; Leda Chatzi; Jonathan Coquet; Pascal Demoly; Weiniu Gan; Judith Garcia-Aymerich; Elena Gimeno-Santos; Chantal Guihenneuc-Jouyaux; Tari Haahtela; Joachim Heinrich; Marie Herr; Cynthia Hohmann; Bénédicte Jacquemin; Jocelyne Just; Marjan Kerkhof; Manolis Kogevinas; Marek L Kowalski; Bart N Lambrecht; Susanne Lau; Karin C Lødrup Carlsen; Dieter Maier; Isabelle Momas; Patricia Noel; Sam Oddie; Susanna Palkonen; Isabelle Pin; Daniela Porta; Antonello Punturieri; Fanny Rancière; Robert A Smith; Barbara Stanic; Renato T Stein; Willem van de Veen; Antoon J.M. van Oosterhout; Raphaelle Varraso; Magnus Wickman; Cisca Wijmenga; John Wright; Gorkem Yaman; Torsten Zuberbier; Jean Bousquet

doi:10.1016/j.jaci.2012.01.047

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Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

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Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

Josep M Antó, Mariona Pinart, Mübeccel Akdis, Charles Auffray, Claus Bachert, Xavier Basagaña, Kai-Håkon Carlsen, Stefano Guerra, Leena von Hertzen, Sabina Illi, …

Journal of Allergy and Clinical Immunology, Vol.129(4), pp.943-954.e4

04/2012

DOI: https://doi.org/10.1016/j.jaci.2012.01.047

Résumé

Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL.

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Titre: Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar
Créateurs - sans rôle: Josep M Antó - Barcelona Institute for Global Health
Mariona Pinart - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Mübeccel Akdis - University of Zurich
Charles Auffray - Institute for Systems Biology
Claus Bachert - Ghent University Hospital
Xavier Basagaña - Center for Research in Environmental Epidemiology
Kai-Håkon Carlsen - Oslo University Hospital
Stefano Guerra - University of Arizona
Leena von Hertzen - Helsinki University Hospital
Sabina Illi - Ludwig-Maximilians-Universität München
Francine Kauffmann - Inserm
Thomas Keil - Charité - Universitätsmedizin Berlin
James P Kiley - National Heart Lung and Blood Institute
Gerard H Koppelman - University of Groningen
Christian Lupinek - Medical University of Vienna
Fernando D Martinez - University of Arizona
Martijn C Nawijn - University of Groningen
Dirkje S Postma - University of Groningen
Valérie Siroux - Inserm
Henriette A Smit - University Medical Center Utrecht
Peter J Sterk - Leiden University Medical Center
Jordi Sunyer - Center for Research in Environmental Epidemiology
Rudolf Valenta - Medical University of Vienna
Sergio Valverde - Universitat Pompeu Fabra
Cezmi A Akdis - University of Zurich
Isabella Annesi-Maesano - Université Toulouse III - Paul Sabatier
Ferran Ballester - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Marta Benet - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Anne Cambon-Thomsen - Laboratoire Epidémiologie et Analyses en Santé Publique : Risques, Maladies Chroniques et Handicaps
Leda Chatzi - University of Crete
Jonathan Coquet - Ghent University
Pascal Demoly - Université de Montpellier
Weiniu Gan - Department of Health and Human Services
Judith Garcia-Aymerich - Center for Research in Environmental Epidemiology
Elena Gimeno-Santos - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Chantal Guihenneuc-Jouyaux - Université Paris Cité
Tari Haahtela - Allergy and Asthma Federation
Joachim Heinrich - Helmholtz Zentrum München
Marie Herr - Université Paris Cité
Cynthia Hohmann - Charité - Universitätsmedizin Berlin
Bénédicte Jacquemin - Centre de recherche en Epidémiologie et Santé des Populations
Jocelyne Just - Université Paris Cité
Marjan Kerkhof - University Medical Center Groningen
Manolis Kogevinas - Barcelona Institute for Global Health
Marek L Kowalski - Medical University of Lodz
Bart N Lambrecht - WHO Collaborating Center for Asthma and Rhinitis
Susanne Lau - Charité - Universitätsmedizin Berlin
Karin C Lødrup Carlsen - Oslo University Hospital
Dieter Maier - Biomax Informatics
Isabelle Momas - Université Paris Cité
Patricia Noel - National Heart Lung and Blood Institute
Sam Oddie - Bradford Royal Infirmary
Susanna Palkonen - European Federation of Allergy and Airways Diseases Patients Associations
Isabelle Pin - Inserm
Daniela Porta - Agenzia Regionale Parchi
Antonello Punturieri - National Institutes of Health
Fanny Rancière - Université Paris Cité
Robert A Smith - National Heart Lung and Blood Institute
Barbara Stanic - University of Zurich
Renato T Stein - Pontifícia Universidade Católica do Rio de Janeiro
Willem van de Veen - University of Zurich
Antoon J.M. van Oosterhout - University Medical Center Groningen
Raphaelle Varraso - Centre de recherche en Epidémiologie et Santé des Populations
Magnus Wickman - Sachs' Children and Youth Hospital
Cisca Wijmenga - University Medical Center Groningen
John Wright - Bradford Royal Infirmary
Gorkem Yaman - University of Zurich
Torsten Zuberbier - Charité - Universitätsmedizin Berlin
Jean Bousquet - Hôpital Arnaud de Villeneuve
Détails de publication: Journal of Allergy and Clinical Immunology, Vol.129(4), pp.943-954.e4
Identifiants: 99161095909311
Unité académique: Université de Montpellier
Langue: English
Type de ressource: Journal article
Champs locaux: hal-04323435