Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

Uwe Rudolph; Milton J. Finegold; Susan S. Rich; Gregory R. Harriman; Yogambal Srinivasan; Philippe Brabet; Guylain Boulay; Allan Bradley; Lutz Birnbaumer

doi:10.1038/ng0695-143

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Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

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Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

Uwe Rudolph, Milton J. Finegold, Susan S. Rich, Gregory R. Harriman, Yogambal Srinivasan, Philippe Brabet, Guylain Boulay, Allan Bradley et Lutz Birnbaumer

Nature genetics, Vol.10(2), pp.143-150

01/06/1995

DOI: https://doi.org/10.1038/ng0695-143

PMID: 7663509

Résumé

Agriculture

Animal Genetics and Genomics

Article

Biomedical and Life Sciences

Biomedicine

Cancer Research

Gene Function

Général

Human Genetics

G proteins are involved in cellular signalling and regulate a variety of biological processes including differentiation and development. We have generated mice deficient for the G protein subunit α i2 (Gα i2 ) by homologous recombination in embryonic stem cells. Gα i2 –deficient mice display growth retardation and develop a lethal diffuse colitis with clinical and histopathological features closely resembling ulcerative colitis in humans, including the development of adenocarcinoma of the colon. Prior to clinical symptoms, the mice show profound alterations in thymocyte maturation and function. The study of these animals should provide important insights into the pathogenesis of ulcerative colitis as well as carcinogenesis.

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Détails

Titre: Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice
Créateurs - sans rôle: Uwe Rudolph - Departments of Cell Biology, Baylor College of Medicine, Department of Pharmacology, Baylor College of Medicine, Institute of Pharmacology, University of Zürich
Milton J. Finegold - Department of Pathology, Baylor College of Medicine
Susan S. Rich - Department of Microbiology & Immunology, Baylor College of Medicine
Gregory R. Harriman - Department of Medicine, Baylor College of Medicine
Yogambal Srinivasan - Departments of Cell Biology, Baylor College of Medicine
Philippe Brabet - Departments of Cell Biology, Baylor College of Medicine, Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Rue de la Cardonille
Guylain Boulay - Departments of Cell Biology, Baylor College of Medicine, Department of Anesthesiology, UCLA School of Medicine, Center for the Health Sciences
Allan Bradley - Department of Department of Molecular and Human Genetics, Baylor College of Medicine, Department of Howard Hughes Medical Institute, Baylor College of Medicine
Lutz Birnbaumer - Departments of Cell Biology, Baylor College of Medicine, Department of Medicine, Baylor College of Medicine, Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Department of Division of Neuroscience, Baylor College of Medicine, Department of Anesthesiology, UCLA School of Medicine, Center for the Health Sciences
Détails de publication: Nature genetics, Vol.10(2), pp.143-150
Éditeur: Nature Publishing Group US
Nombre de pages: 8
Identifiants: 99140104009311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article