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Two novel tumours with NTRK2 fusion in the methylation class of extraventricular neurocytomas, including one intraventricular
Article de revue   Open Access   Avec comité de lecture

Two novel tumours with NTRK2 fusion in the methylation class of extraventricular neurocytomas, including one intraventricular

Emmanuelle Uro-Coste, Arnault Tauziède-Espariat, Charlotte Dubucs, Dan Christian Chiforeanu, Aurore Siegfried, Yvan Nicaise, Luc Bauchet, Laurent Riffaud, Franck Bielle, Alexandre Vasiljevic, …
Brain Pathology, Vol.34(3)
2024
PMCID: PMC11006991
PMID: 37994695

Résumé

We report here about two novel tumours classified as extraventricular neurocytomas (EVN) using DNA-methylation profiling, associated with NTRK2 fusions instead of the usual FGFR1 alterations so far attributed to this tumoural entity. We present the second detailed case of an intraventricular presentation in the MC EVN. Our findings broaden the spectrum of MC EVN and have implications in terms of diagnosis, therapy and terminology.

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