Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves.

Jonas Croissant; Arnaud Chaix; Olivier Mongin; Miao Wang; Sébastien Clément; Laurence Raehm; Jean-Olivier Durand; Vincent Hugues; Mireille Blanchard-Desce; Marie Maynadier; Audrey Gallud; Magali Gary-Bobo; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Ferris Daniel P.; Derrick Tarn; Jeff Zink

doi:10.1002/smll.201400042

Article de revue

Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves.

Jonas Croissant, Arnaud Chaix, Olivier Mongin, Miao Wang, Sébastien Clément, Laurence Raehm, Jean-Olivier Durand, Vincent Hugues, Mireille Blanchard-Desce, Marie Maynadier, …

Small Press, Vol.10(9), pp.1752-1755

14/05/2014

DOI: https://doi.org/10.1002/smll.201400042

Résumé

light

mesoporous silica nanoparticles

nanovalves

cancer

drug delivery

two-photon

Mesoporous silica nanoparticles (MSN) are functionalized in the walls with an original fluorophore with a high two-photon absorption cross-section. The pores of the MSN filled with anticancer drug are blocked with a pseudo-rotaxane constituted by an azobenzene stalk and a β-cyclodextrin moiety. After incubation of the nanosystem with MCF-7 breast cancer cells, two-photon irradiation at low power is used to image the cells. At high power, cancer cell killing is observed due to the two-photon-triggered opening of the pores through FRET and the release of the anticancer drug from the MSN.

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Détails

Titre: Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves.
Créateurs - sans rôle: Jonas Croissant - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Arnaud Chaix - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Olivier Mongin - Centre National de la Recherche Scientifique
Miao Wang - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Sébastien Clément - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Laurence Raehm - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Jean-Olivier Durand - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Vincent Hugues - Université de Bordeaux
Mireille Blanchard-Desce - Centre National de la Recherche Scientifique
Marie Maynadier - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Audrey Gallud - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Magali Gary-Bobo - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Marcel Garcia - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Jie Lu - University of California, Los Angeles
Fuyuhiko Tamanoi - University of California, Los Angeles
Ferris Daniel P. - Exotic Materials Institute
Derrick Tarn - University of California, Los Angeles
Jeff Zink - Exotic Materials Institute
Détails de publication: Small Press, Vol.10(9), pp.1752-1755
Identifiants: 99161430609311
Unité académique: Institut Charles Gerhardt Montpellier - ICGM; Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-01093766