Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis

Obolbek Turapov; Francesca Forti; Baleegh Kadhim; Daniela Ghisotti; Jad Sassine; Anna Straatman-Iwanowska; Andrew Bottrill; Patrick Moynihan; Russell Wallis; Philippe Barthe; Martin Cohen-Gonsaud; Paul Ajuh; Waldemar Vollmer; Galina Mukamolova

doi:10.1016/j.celrep.2018.09.004

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Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis

Journal article

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Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis

Obolbek Turapov, Francesca Forti, Baleegh Kadhim, Daniela Ghisotti, Jad Sassine, Anna Straatman-Iwanowska, Andrew Bottrill, Patrick Moynihan, Russell Wallis, Philippe Barthe, …

Cell Reports, Vol.25(1), pp.57-67.e5

10/2018

DOI: https://doi.org/10.1016/j.celrep.2018.09.004

Abstract

Highlights d PknB is not critical for M. tuberculosis growth in osmoprotective medium d CwlM is the major substrate of PknB d Phosphorylation controls localization of CwlM in the cytoplasmic and membrane fractions d Phospho-CwlM binds FhaA, and non-phospho-CwlM interacts with the essential MurJ linker

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Title: Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis
Creators - without role: Obolbek Turapov - University of Leicester
Francesca Forti - University of Milan
Baleegh Kadhim - University of Leicester
Daniela Ghisotti - University of Milan
Jad Sassine - Newcastle University
Anna Straatman-Iwanowska - University of Leicester
Andrew Bottrill - University of Leicester
Patrick Moynihan - University of Birmingham
Russell Wallis - University of Leicester
Philippe Barthe - Université de Montpellier, Centre de Biologie Structurale - CBS
Martin Cohen-Gonsaud - Université de Montpellier, Centre de Biologie Structurale - CBS
Paul Ajuh
Waldemar Vollmer - Newcastle University
Galina Mukamolova - University of Leicester
Publication Details: Cell Reports, Vol.25(1), pp.57-67.e5
Identifiers: 9944310509311
Academic Unit: Centre de Biologie Structurale - CBS
Language: English
Resource Type: Journal article
Local Fields: hal-02363541