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Triphenylphosphine catalyzed formation of functionalized 2-aminothiophenes
Journal article   Peer reviewed

Triphenylphosphine catalyzed formation of functionalized 2-aminothiophenes

David Null Virieux, Anne-Françoise Guillouzic and Henri-Jean Cristau
Heteroatom Chemistry, Vol.18(13), pp.312-315
09/04/2007

Abstract

Triphenylphosphine was used as a nucleophilic catalyst in the addition-cyclization reaction of phenyl isothiocyanate with electron-deficient allenes. This strategy offers a new approach for the synthesis of 2-aminothiophenes under neutral conditions.
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