Tripartite polyionic complex (PIC) micelles as non-viral vectors for mesenchymal stem cell siRNA transfection

Sophie Raisin; Marie Morille; Claire Bony; Danièle Noël; Jean-Marie Devoisselle; Emmanuel Belamie

doi:10.1039/c7bm00384f

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Journal article

Tripartite polyionic complex (PIC) micelles as non-viral vectors for mesenchymal stem cell siRNA transfection

Sophie Raisin, Marie Morille, Claire Bony, Danièle Noël, Jean-Marie Devoisselle and Emmanuel Belamie

Biomaterials Science, Vol.5(9), pp.1910 - 1921

2017

DOI: https://doi.org/10.1039/c7bm00384f

Abstract

In this study, we demonstrate that PIC micelles readily form at physiological pH in the presence of siRNA and disassemble at a pH close to that of endosomes. Internalization of the micelles in primary MSC results in the down-regulation of Runx2.

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Title: Tripartite polyionic complex (PIC) micelles as non-viral vectors for mesenchymal stem cell siRNA transfection
Creators - without role: Sophie Raisin - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Marie Morille - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Claire Bony - Université de Montpellier, Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Danièle Noël - Université de Montpellier, Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Jean-Marie Devoisselle - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Emmanuel Belamie - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Publication Details: Biomaterials Science, Vol.5(9), pp.1910 - 1921
Identifiers: 9937652709311
Academic Unit: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB; Institut Charles Gerhardt Montpellier - ICGM
Language: English
Resource Type: Journal article
Local Fields: hal-01834627