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Treatment failure of methicillin-resistant Staphylococcus aureus endocarditis with linezolid
Article de revue

Treatment failure of methicillin-resistant Staphylococcus aureus endocarditis with linezolid

Philippe Corne, Hélène Marchandin, Jean-Christophe Macia et Olivier Jonquet
Scandinavian journal of infectious diseases, Vol.37(11-12), pp.946-949
2005
PMID: 16308242

Résumé

Acetamides - therapeutic use Anti-Bacterial Agents - therapeutic use Endocarditis, Bacterial - drug therapy Endocarditis, Bacterial - microbiology Fatal Outcome Humans Linezolid Male Methicillin Resistance Middle Aged Mitral Valve - microbiology Oxazolidinones - therapeutic use Recurrence Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Treatment Failure Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use Vancomycin - therapeutic use
We report a case of methicillin-resistant Staphylococcus aureus endocarditis treated by vancomycin and cotrimoxazole switched to oral linezolid alone with a complete resolution of the vegetation. Two months after discontinuation of treatment, the patient presented a relapse confirmed by pulsed-field gel electrophoresis involving the same linezolid-susceptible strain and rapidly died.

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