Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees

Jonathan L. Heeney; Erik Rutjens; Ernst J. Verschoor; Henk Niphuis; Peter ten Haaft; Scott Rouse; Hazel McClure; Sunita Balla-Jhagjhoorsingh; Willy Bogers; Mary Salas; Kathy Cobb; Luc Kestens; David Davis; Guido van der Groen; Valerie Courgnaud; Martine Peeters; Krishna K. Murthy

doi:10.1128/JVI.00382-06

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Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees

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Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees

Jonathan L. Heeney, Erik Rutjens, Ernst J. Verschoor, Henk Niphuis, Peter ten Haaft, Scott Rouse, Hazel McClure, Sunita Balla-Jhagjhoorsingh, Willy Bogers, Mary Salas, …

Journal of virology, Vol.80(14), pp.7208-7218

01/07/2006

DOI: https://doi.org/10.1128/JVI.00382-06

PMID: 16809326

Résumé

Genetic Diversity and Evolution

Current data suggest that the human immunodeficiency virus type 1 (HIV-1) epidemic arose by transmission of simian immunodeficiency virus (SIV) SIVcpz from a subspecies of common chimpanzees (Pan troglodytes troglodytes) to humans. SIVcpz of chimpanzees is itself a molecular chimera of SIVs from two or more different monkey species, suggesting that recombination was made possible by coinfection of one individual animal with different lentiviruses. However, very little is known about SIVcpz transmission and the susceptibility to lentivirus coinfection of its natural host, the chimpanzee. Here, it is revealed that either infected plasma or peripheral blood mononuclear cells readily confer infection when exposure occurs by the intravenous or mucosal route. Importantly, the presence of preexisting HIV-1 infection did not modify the kinetics of SIVcpz infection once it was established by different routes. Although humoral responses appeared as early as 4 weeks postinfection, neutralization to SIVcpz-ANT varied markedly between animals. Analysis of the SIVcpz env sequence over time revealed the emergence of genetic viral variants and persistent SIVcpz RNA levels of between 104 and 105 copies/ml plasma regardless of the presence or absence of concurrent HIV-1 infection. These unique data provide important insight into possible routes of transmission, the kinetics of acute SIVcpz infection, and how readily coinfection with SIVcpz and other lentiviruses may be established as necessary preconditions for potential recombination.

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Titre: Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees
Créateurs - sans rôle: Jonathan L. Heeney - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Erik Rutjens - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Ernst J. Verschoor - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Henk Niphuis - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Peter ten Haaft - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Scott Rouse - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Hazel McClure - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Sunita Balla-Jhagjhoorsingh - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Willy Bogers - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Mary Salas - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Kathy Cobb - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Luc Kestens - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
David Davis - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Guido van der Groen - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Valerie Courgnaud - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Martine Peeters - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Krishna K. Murthy - Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium, Laboratoire Retrovirus UMR 145, Institut de Recherche pour le Développement, and University of Montpellier, Montpellier, France
Détails de publication: Journal of virology, Vol.80(14), pp.7208-7218
Éditeur: American Society for Microbiology
Nombre de pages: 11
Identifiants: 99154045609311
Unité académique: Institut de Génétique Moléculaire de Montpellier - IGMM; Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article