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Transition-Metal-Free Synthesis of Biarylmethanes from Aryl Iodides and Benzylic Ketones
Article de revue   Avec comité de lecture

Transition-Metal-Free Synthesis of Biarylmethanes from Aryl Iodides and Benzylic Ketones

Martin Pichette drapeau, Anis Tlili, Yassir Zaid, Dounia Toummini, Fouad Ouazzani chahdi, Jean-Marc Sotiropoulos, Thierry Ollevier et Marc Taillefer
Chemistry - A European Journal, Vol.24(17449)
2018

Résumé

metal-free superbase ketones biarylmethanes C−C coupling
An original metal-free procedure for the synthesis of biarylmethanes is disclosed herein. The reactions occur with high selectivity starting from aryl iodides and benzylic ketones in the presence of superbasic media (CsOH/DMSO). This procedure allows a straightforward access to a wide range of biarylmethane derivatives substituted with electron-withdrawing and -donating substituents.

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