Résumé
The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.
- Titre
- Towards host-directed therapies for tuberculosis
- Créateurs - sans rôle
- Alimuddin Zumla - University College London Hospitals NHS Foundation TrustMarkus Maeurer - Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet and Center for Allogeneic Stem Cell Transplantation, Karolinska Hospital, Hälsovägen, SE-14186 Stockholm, SwedenJeremiah Chakaya - Kenya Medical Research InstituteMichael Hoelscher - Ludwig-Maximilians-Universität MünchenFrancine Ntoumi - Fondation Congolaise pour la Recherche Médicale, Brazzaville, Republic of Congo and Institute for Tropical Medicine, University of Tübingen, GermanyRoxana Rustomjee - Medical Research Council, Cape Town, South AfricaCristina Vilaplana - Unitat de Tuberculosi Experimental Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i PujolEdifici Laboratoris de Recerca Can Ruti Campus, Barcelona, SpainDorothy Yeboah-Manu - Bacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, GhanaVoahangy Rasolof - Mycobacteria Unit, Institut Pasteur de Madagascar, Antananarivo, MadagascarPaula Munderi - Medical Research Council/Uganda Virus Research Institute, Research Unit on AIDS, Entebbe, UgandaNalini Singh - Inkosi Albert Luthuli Central Hospital and King DinuZulu Hospital, Durban, South AfricaEleni Aklillu - Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, SwedenNesri Padayatchi - Centre for AIDS Prevention Research in South Africa (CAPRISA), SAMRC CAPRISA HIV -TB pathogenesis and treatment research unit, Durban, South AfricaEusebio Macete - Centro de Investigação em Saude de Manhiça, Maputo, MozambiqueNathan Kapata - UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, ZambiaModest Mulenga - Tropical Diseases Research CentreGibson Kibiki - Kilimanjaro Clinical Research Institute (KCRI), Kilimanjaro, TanzaniaSayoki Mfinanga - Muhimbili Medical Research Centre National Institute for Medical Research (NIMR), Dar es Salaam, TanzaniaThomas NyirendaLeonard Maboko - Mbeya Medical Research Centre, Mbeya, TanzaniaAlberto Garcia-Basteiro - Centro de Investigação em Saude de Manhiça, Maputo, MozambiqueNiaina Rakotosamimanana - Mycobacteria Unit, Institut Pasteur de Madagascar, Antananarivo, MadagascarMatthew Bates - UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, ZambiaPeter Mwaba - UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, ZambiaKlaus Reither - Swiss Tropical and Public Health Institute, Basel, SwitzerlandSebastien Gagneux - Swiss Tropical and Public Health Institute, Basel, SwitzerlandSarah Edwards - Ethics and Governance, NIHR BRC at University College London Hospitals NHS Trust, London, United KingdomElirehema Mfinanga - Ifakara Health Institute, Bagamoyo, TanzaniaSalim Abdulla - Ifakara Health Institute, Dar-es-Salaam, TanzaniaPere-Joan Cardona - Unitat de Tuberculosi Experimental Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i PujolEdifici Laboratoris de Recerca Can Ruti Campus, Barcelona, SpainJames B W Russell - Department of Internal Medicine, Connaught Hospital, College of Medicine and Allied Health Sciences, University of Sierra Leone, Sierra LeoneVanya Gant - Department of Microbiology, University College London Hospitals NHS Foundation Trust, London, UKMahdad Noursadeghi - 1] Division of Infection and Immunity at the University College London (UCL), London, UK and National Institute of Health Research's Biomedical Research Centre UCL Hospitals National Health Service Foundation Trust, Royal Free Campus, 2nd Floor, Rowland Hill Street, London NW3 2PF, UK. Department of Microbiology, University College London Hospitals NHS Foundation Trust, London, UKPaul Elkington - Respiratory Medicine department, Southampton University, Southampton, UKMaryline Bonnet - Epicentre, IRD, Paris, FranceClara Menendez - ISGlobal, Barcelona Institute for Global health, Barcelona, Spain. Immunology Unit-Laboratoire Bactériologie Virologie, Le DantecTandakha N Dieye - Hospital, Laboratories of the National Blood Transfusion Center, SenegalBassirou Diarra - SEREFO (HIV/TB Research and Training CenteHIV/TB Research and Training Center, FMOS, University of STT, Bamako, MaliAlmoustapha Maiga - SEREFO (HIV/TB Research and Training CenteHIV/TB Research and Training Center, FMOS, University of STT, Bamako, MaliAbraham Aseffa - Armaeur Hansen Resrach Institute (AHRI), Addis Ababa, EthiopiaShreemanta Parida - Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet and Center for Allogeneic Stem Cell Transplantation, Karolinska Hospital, Hälsovägen, SE-14186 Stockholm, SwedenChristian Wejse - Aarhus UniversityEskild Petersen - Department of Infectious Diseases, Aarhus University, Aarhus, DenmarkPontiano Kaleebu - Medical Research Council/Uganda Virus Research Institute, Research Unit on AIDS, Entebbe, UgandaMatt Oliver - Results UK, London, United KingdomGill Craig - School of Health Sciences, City University London, City University, London, UKTumena Corrah - Department of Infectious and Tropical Diseases, Northwick Park Hospital, London, UKLeopold Tientcheu - Medical Research Council, Banjul, GambiaMartin Antonio - Medical Research Council, Banjul, GambiaMartin Rao - Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet and Center for Allogeneic Stem Cell Transplantation, Karolinska Hospital, Hälsovägen, SE-14186 Stockholm, SwedenTimothy D McHugh - Division of Infection and Immunity at the University College London (UCL), London, UK and National Institute of Health Research's Biomedical Research Centre UCL Hospitals National Health Service Foundation Trust, Royal Free Campus, 2nd Floor, Rowland Hill Street, London NW3 2PF, UKAziz Sheikh - Centre of Medical Informatics, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UKGiuseppe Ippolito - National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, ItalyGita Ramjee - HIV prevention Research Unit, MRC, Durban South AfricaStefan H E Kaufmann - Max Planck Institute, Berlin, GermanyGavin Churchyard - Aurum Institute, Johannesburg, South AfricaAndrie Steyn - KwaZulu-Natal Research Institute for Tuberculosis &HIV, Nelson R. Mandela School of Medicine, K-RITH Tower Building, Durban, South AfricaMartin Grobusch - University of AmsterdamIan Sanne - Right to care, University of Witwatersrand, Johannesburg, South AfricaNeil Martinson - Public Health research Unit, Soweto, South AfricaRajhmun Madansein - Department of Cardiothoracic Surgery, University of KwaZulu Natal, Inkosi Albert Luthuli Central Hospital and King DinuZulu Hospital, Durban, South AfricaRobert J Wilkinson - Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa and Francis Crick Institute Mill Hill Laboratory, London, UKBongani Mayosi - University of Cape TownMarco Schito - Critical Path InstituteRobert S Wallis - Aurum Institute, Johannesburg, South AfricaHost-Directed Therapies Network
- Détails de publication
- Nature reviews. Drug discovery, Vol.14(8), pp.511-512
- Note de subvention
- MC_U190074190 / Medical Research Council 104803 / Wellcome Trust MC_U190081991 / Medical Research Council
- Identifiants
- 99158681309311
- Unité académique
- Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
- Langue
- English
- Type de ressource
- Journal article