Toward new camptothecins. Part 5: On the synthesis of precursors for the crucial Friedlander reaction

Thomas Boisse; Laurent Gavara; Jean-Pierre Henichart; Benoit Rigo; Philippe Gautret

doi:10.1016/j.tet.2009.01.077

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Toward new camptothecins. Part 5: On the synthesis of precursors for the crucial Friedlander reaction

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Toward new camptothecins. Part 5: On the synthesis of precursors for the crucial Friedlander reaction

Thomas Boisse, Laurent Gavara, Jean-Pierre Henichart, Benoit Rigo et Philippe Gautret

Tetrahedron, Vol.65(12), pp.2455-2466

21/03/2009

DOI: https://doi.org/10.1016/j.tet.2009.01.077

Résumé

Chemistry

Chemistry, Organic

Physical Sciences

Science & Technology

The synthesis of potential precursors of ketones, which could be used to obtain camptothecin analogs, is described. Noteworthy is the difference of reactivity between indolizinone and pyrrolidinoquinazolinone heterocycle. (C) 2009 Elsevier Ltd. All rights reserved.

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Détails

Titre: Toward new camptothecins. Part 5: On the synthesis of precursors for the crucial Friedlander reaction
Créateurs - sans rôle: Thomas Boisse - Ecole Hautes Etud Ingenieur, EA 2692, F-59046 Lille, France
Laurent Gavara - Ecole Hautes Etud Ingenieur, EA 2692, F-59046 Lille, France
Jean-Pierre Henichart - Univ Lille 2, Inst Chim Pharmaceut Albert Lespagnol, EA 2692, F-59006 Lille, France
Benoit Rigo - Ecole Hautes Etud Ingenieur, EA 2692, F-59046 Lille, France
Philippe Gautret - Ecole Hautes Etud Ingenieur, EA 2692, F-59046 Lille, France
Détails de publication: Tetrahedron, Vol.65(12), pp.2455-2466
Éditeur: Elsevier
Nombre de pages: 12
Note de subvention: Region Nord-Pas-de-Calais; Region Hauts-de-France
Identifiants: 99138900109311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article