Résumé
The first total synthesis of ent-15(RS)-2,3-dinor-5,6-dihydro-8-epi-PGF2α 1 is described using diacetone-D-glucose as starting material. The major urinary metabolite of the isoprostane 8-epi-PGF2α is 2,3-dinor-5,6-dihydro-8-epi-PGF2α, which is a potent lipid peroxidation index to obtain an integrated assessment of oxidative stress in humans.
The first total synthesis of ent-15(RS)-2,3-dinor-5,6-dihydro-8-epi-PGF2α. 1 is described using D-glucose as starting material. This route allows the synthesis of the enantiomer which is the major urinary metabolite in humans of 8-epi-PGF2α.