Résumé
The first total synthesis of 15(RS)-5,6-dehydro-8-
epi-PGF
2α methyl ester
1 with high stereoselectivity and good yield, is described using D-glucose as starting material. This novel isoprostane is a potent precursor of labelled (deutered and/or tritiated) 8-
epi-PGF
2α, an useful tool for biological studies.
The first total synthesis of 15(RS)-5,6-dehydro-8-
epi-PGF
2
α
methyl ester
1 with high stereoselectivity and good yield, is described using D-glucose as starting material.