The receptor of the type I interferon family.

G. Uzé; G. Schreiber; J. Piehler; S. Pellegrini

doi:10.1007/978-3-540-71329-6_5

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The receptor of the type I interferon family.

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The receptor of the type I interferon family.

G. Uzé, G. Schreiber, J. Piehler et S. Pellegrini

Current Topics in Microbiology and Immunology, Vol.316, pp.71-95

2007

DOI: https://doi.org/10.1007/978-3-540-71329-6_5

PMID: 17969444

Résumé

Humans

Models, Molecular

Molecular Sequence Data

Receptor, Interferon alpha-beta

Amino Acid Sequence

All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how a multitude of subtypes can generate similar signaling outputs but also govern specific cellular responses. This review summarizes results from the last decade that contributed to our current state of knowledge of IFN-receptor complex structure and assembly.

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Détails

Titre: The receptor of the type I interferon family.
Créateurs - sans rôle: G. Uzé - Université de Montpellier, Laboratory of Pathogens and Host Immunity - LPHI
G. Schreiber - Weizmann Institute of Science
J. Piehler - Goethe University Frankfurt
S. Pellegrini - Toxicologie, Pharmacologie et Signalisation Cellulaire
Détails de publication: Current Topics in Microbiology and Immunology, Vol.316, pp.71-95
Identifiants: 99161727909311
Unité académique: Laboratory of Pathogens and Host Immunity - LPHI
Langue: English
Type de ressource: Journal article
Champs locaux: hal-00202867