Abstract
Study of the ability to inhibit CypD peptidyl-prolyl cis-trans isomerase (PPIase) activity and of mitoprotective properties
CypD PPIase activity assay
Mitochondrial swelling assay
Mitochondrial calcium retention capacity assay
Isolated mouse liver mitochondria 1 compound
Study of the ability to inhibit mitochondrial permeability transition pore opening and cell death
In vitro hypoxia/reoxygenation model
Mouse hepatocyte cell line
Study of the hepatoprotective properties
Identification of credible lead compound for subsequent clinical development
In vivo hepatic ischemia/reperfusion injury model
compounds
Cyclophilin inhibitor synthesis
Chemical optimization R1