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The large first periplasmic loop of SecD and SecF plays an important role in SecDF functioning
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The large first periplasmic loop of SecD and SecF plays an important role in SecDF functioning

Nico Nouwen, Magdalena Piwowarek, Greetje Berrelkamp et Arnold J M Driessen
Journal of bacteriology, Vol.187(16), pp.5857-5860
01/08/2005
DOI: https://doi.org/10.1128/jb.187.16.5857-5860.2005
PMID: 16077136

Résumé

Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Cytoplasm - metabolism Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Deletion Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Transport Proteins - chemistry Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mutagenesis Protein Structure, Tertiary
A remarkable feature of proteins of the SecD and SecF family involved in protein translocation is that they possess a very large first periplasmic domain. Here we report that this large first periplasmic domain is not required for the SecD-SecF interaction but that it is important for catalyzing protein translocation.

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