Résumé
The in vitro antiplasmodial activity of some dihydrostilbenamides, phtalazinones, imidazo[2,1-
a]isoindole and pyrimido[2,1-
a]isoindole derivatives related to the natural dihydrostilbenoid isonotholaenic acid is reported. The evaluation was performed on cultures of F32 strain of
Plasmodium falciparum and potent representative compounds were also evaluated in the ferriprotoporphyrin IX biomineralization inhibition test (FBIT). Compounds having the imidazo[2,1-
a]isoindole skeleton were the most active and one compound of this group resulted to be as potent as chloroquine, but acting through a mechanism different that of the inhibition of heme biomineralization.
The in vitro antiplasmodial and the ferriprotoporphyrin IX biomineralization activities of some imidazo[2,1-
a]isoindole and related compounds are reported.