The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

Stephane Cociancich; Alexander Pesic; Daniel Petras; Stefanie Uhlmann; Julian Kretz; Vivien Schubert; Laura Vieweg; Sandrine Duplan; Melanie Marguerettaz; Julie Noell; Isabelle Pieretti; Manuela Hugelland; Sebastian Kemper; Andi Mainz; Philippe Rott; Monique Royer; Roderich D. Suessmuth

doi:10.1038/nchembio.1734

Retour

The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

Article de revue

Avec comité de lecture

The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

Stephane Cociancich, Alexander Pesic, Daniel Petras, Stefanie Uhlmann, Julian Kretz, Vivien Schubert, Laura Vieweg, Sandrine Duplan, Melanie Marguerettaz, Julie Noell, …

Nature chemical biology, Vol.11(3), pp.195-U178

01/03/2015

DOI: https://doi.org/10.1038/nchembio.1734

PMID: 25599532

Résumé

Biochemistry & Molecular Biology

Life Sciences & Biomedicine

Science & Technology

Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.

Indicateurs

1 Consultations de la notice

Détails

Titre: The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine
Créateurs - sans rôle: Stephane Cociancich - Cirad, UMR Biol & Genet Interact Plante Parasite, Montpellier, France
Alexander Pesic - Tech Univ Berlin, Inst Chem, Berlin, Germany
Daniel Petras - Tech Univ Berlin, Inst Chem, Berlin, Germany
Stefanie Uhlmann - Tech Univ Berlin, Inst Chem, Berlin, Germany
Julian Kretz - Tech Univ Berlin, Inst Chem, Berlin, Germany
Vivien Schubert - Tech Univ Berlin, Inst Chem, Berlin, Germany
Laura Vieweg - Tech Univ Berlin, Inst Chem, Berlin, Germany
Sandrine Duplan - Cirad, UMR Biol & Genet Interact Plante Parasite, Montpellier, France
Melanie Marguerettaz - Cirad, UMR Biol & Genet Interact Plante Parasite, Montpellier, France
Julie Noell - Cirad, UMR Biol & Genet Interact Plante Parasite, Montpellier, France
Isabelle Pieretti - Cirad, UMR Biol & Genet Interact Plante Parasite, Montpellier, France
Manuela Hugelland - Tech Univ Berlin, Inst Chem, Berlin, Germany
Sebastian Kemper - Tech Univ Berlin, Inst Chem, Berlin, Germany
Andi Mainz - Tech Univ Berlin, Inst Chem, Berlin, Germany
Philippe Rott - Cirad, UMR Biol & Genet Interact Plante Parasite, Montpellier, France
Monique Royer - Cirad, UMR Biol & Genet Interact Plante Parasite, Montpellier, France
Roderich D. Suessmuth - Tech Univ Berlin, Inst Chem, Berlin, Germany
Détails de publication: Nature chemical biology, Vol.11(3), pp.195-U178
Éditeur: NATURE PORTFOLIO
Nombre de pages: 5
Note de subvention: ANR-09-BLAN-0413 / Agence Nationale de la Recherche (ANR) ANR-09-BLAN-0413-01 / Agence Nationale de la Recherche; Agence Nationale de la Recherche (ANR) DFG SU239/11-1; SU 18-1 / Deutsche Forschungsgemeinschaft; German Research Foundation (DFG) Cluster of Excellence 'Unifying Concepts in Catalysis (UniCat)' (DFG); German Research Foundation (DFG)
Identifiants: 99157212609311
Unité académique: Plant Health Institute of Montpellier - PHIM
Langue: English
Type de ressource: Journal article