The genome of the colonial hydroid Hydractinia reveals that their stem cells use a toolkit of evolutionarily shared genes with all animals

Christine E Schnitzler; E Sally Chang; Justin Waletich; Gonzalo Quiroga-Artigas; Wai Yee Wong; Anh-Dao Nguyen; Sofia N Barreira; Liam B Doonan; Paul Gonzalez; Sergey Koren; James M Gahan; Steven M Sanders; Brian Bradshaw; Timothy Q DuBuc; Febrimarsa; Danielle de Jong; Eric P Nawrocki; Alexandra Larson; Samantha Klasfeld; Sebastian G Gornik; R Travis Moreland; Tyra G Wolfsberg; Adam M Phillippy; James C Mullikin; Oleg Simakov; Paulyn Cartwright; Matthew Nicotra; Uri Frank; Andreas D Baxevanis

doi:10.1101/gr.278382.123

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The genome of the colonial hydroid Hydractinia reveals that their stem cells use a toolkit of evolutionarily shared genes with all animals

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The genome of the colonial hydroid Hydractinia reveals that their stem cells use a toolkit of evolutionarily shared genes with all animals

Christine E Schnitzler, E Sally Chang, Justin Waletich, Gonzalo Quiroga-Artigas, Wai Yee Wong, Anh-Dao Nguyen, Sofia N Barreira, Liam B Doonan, Paul Gonzalez, Sergey Koren, …

Genome research, Vol.34(3), pp.498-513

25/04/2024

DOI: https://doi.org/10.1101/gr.278382.123

PMID: 38508693

Résumé

Animals

Evolution, Molecular

Genome

Hydrozoa - genetics

Male

Phylogeny

Single-Cell Analysis - methods

Stem Cells - metabolism

Transcriptome

is a colonial marine hydroid that shows remarkable biological properties, including the capacity to regenerate its entire body throughout its lifetime, a process made possible by its adult migratory stem cells, known as i-cells. Here, we provide an in-depth characterization of the genomic structure and gene content of two species, and , placing them in a comparative evolutionary framework with other cnidarian genomes. We also generated and annotated a single-cell transcriptomic atlas for adult male and identified cell-type markers for all major cell types, including key i-cell markers. Orthology analyses based on the markers revealed that 's i-cells are highly enriched in genes that are widely shared amongst animals, a striking finding given that has a higher proportion of phylum-specific genes than any of the other 41 animals in our orthology analysis. These results indicate that 's stem cells and early progenitor cells may use a toolkit shared with all animals, making it a promising model organism for future exploration of stem cell biology and regenerative medicine. The genomic and transcriptomic resources for presented here will enable further studies of their regenerative capacity, colonial morphology, and ability to distinguish self from nonself.

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Titre: The genome of the colonial hydroid Hydractinia reveals that their stem cells use a toolkit of evolutionarily shared genes with all animals
Créateurs - sans rôle: Christine E Schnitzler - Department of Biology, University of Florida, Gainesville, Florida 32611, USA
E Sally Chang - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
Justin Waletich - Department of Biology, University of Florida, Gainesville, Florida 32611, USA
Gonzalo Quiroga-Artigas - Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier, Centre National de la Recherche Scientifique, 34293 Montpellier CEDEX 05, France
Wai Yee Wong - Department for Neurosciences and Developmental Biology, University of Vienna, 1030 Vienna, Austria
Anh-Dao Nguyen - Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Sofia N Barreira - Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Liam B Doonan - Centre for Chromosome Biology, College of Science and Engineering, University of Galway, Galway H91 W2TY, Ireland
Paul Gonzalez - Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Sergey Koren - National Human Genome Research Institute
James M Gahan - Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
Steven M Sanders - Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Brian Bradshaw - Centre for Chromosome Biology, College of Science and Engineering, University of Galway, Galway H91 W2TY, Ireland
Timothy Q DuBuc - Department of Biology, Swarthmore College, Swarthmore, Pennsylvania 19081, USA
Febrimarsa - Pharmaceutical Biology Laboratory, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jawa Tengah 57169, Indonesia
Danielle de Jong - Department of Biology, University of Florida, Gainesville, Florida 32611, USA
Eric P Nawrocki - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
Alexandra Larson - Whitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, Florida 32080, USA
Samantha Klasfeld - Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Sebastian G Gornik - Center for Organismal Studies, University of Heidelberg, 69117 Heidelberg, Germany
R Travis Moreland - Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Tyra G Wolfsberg - Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Adam M Phillippy - National Human Genome Research Institute
James C Mullikin - NIH Intramural Sequencing Center, Rockville, Maryland 20852, USA
Oleg Simakov - Department for Neurosciences and Developmental Biology, University of Vienna, 1030 Vienna, Austria
Paulyn Cartwright - Department of Evolution and Ecology, University of Kansas, Lawrence, Kansas 66045, USA
Matthew Nicotra - Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Uri Frank - Centre for Chromosome Biology, College of Science and Engineering, University of Galway, Galway H91 W2TY, Ireland
Andreas D Baxevanis
Détails de publication: Genome research, Vol.34(3), pp.498-513
Note de subvention: R35 GM138156 / NIGMS NIH HHS ZIB LM622435 / Intramural NIH HHS ZIA HG000140 / Intramural NIH HHS
Identifiants: 99136570509311
Unité académique: Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Langue: English
Type de ressource: Journal article