- Title
- The cAMP binding protein Epac regulates cardiac myofilament function The effects of Epac activation on myofilament Ca 2 sensitivity and on cTnI and cMyBP-C phosphorylation were independent of PKA and were blocked by protein kinase C (PKC) and Ca 2 calmodulin kinase II (CaMKII) inhibitors. Altogether these findings identify Epac as a new regulator of myofilament function. calmodulin kinase II contraction exchange protein activated by cyclic AMP sarcomeric proteins protein kinase C
- Creators - without role
- Olivier Cazorla - InsermAlexandre Lucas - Laboratory Signaling and Cardiovascular PathophysiologyFlorence Poirier - Institut Galien Paris-SaclayAlain Lacampagne - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExpF. Lezoualc'HJoseph A Beavo
- Publication Details
- Proceedings of the National Academy of Sciences of the United States of America, Vol.106(33), pp.14144 - 14149
- Identifiers
- 9946900409311
- Academic Unit
- Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
- Language
- English
- Resource Type
- Journal article
- Local Fields
- hal-01824357
Journal article
The cAMP binding protein Epac regulates cardiac myofilament function The effects of Epac activation on myofilament Ca 2 sensitivity and on cTnI and cMyBP-C phosphorylation were independent of PKA and were blocked by protein kinase C (PKC) and Ca 2 calmodulin kinase II (CaMKII) inhibitors. Altogether these findings identify Epac as a new regulator of myofilament function. calmodulin kinase II contraction exchange protein activated by cyclic AMP sarcomeric proteins protein kinase C
Proceedings of the National Academy of Sciences of the United States of America, Vol.106(33), pp.14144 - 14149
18/08/2009
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