The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study

Sarowar Muhammad Golam; Christer Janson; Richard Beasley; J Mark Fitzgerald; Tim Harrison; Bradley Chipps; Rod Hughes; Hana Müllerová; José María Olaguibel; Eleni Rapsomaniki; Helen K Reddel; Mohsen Sadatsafavi; Gabriel Benhabib; Piushkumar Mandhane; Xavier Bocca Ruiz; Andrew Mcivor; Ricardo Del Olmo; Bonavuth Pek; Raul Eduardo Lisanti; Robert Petrella; Gustavo Marino; Daniel Stollery; Walter Mattarucco; Meihua Chen; Juan Nogueira; Yan Chen; Maria Parody; Wei Gu; Pablo Pascale; Kim Ming Christopher Hui; Pablo Rodriguez; Manxiang Li; Damian Silva; Shiyue Li; Graciela Svetliza; Lijun Ma; Carlos F Victorio; Guangyue Qin; Roxana Willigs Rolon; Weidong Song; Anahi Yañez; Wei Tan; Stuart Baines; Yijun Tang; Simon Bowler; Chen Wang; Peter Bremner; Tan Wang; Sheetal Bull; Fuqiang Wen; Patrick Carroll; Feng Wu; Mariam Chaalan; Pingchao Xiang; Claude Farah; Zuke Xiao; Gary Hammerschlag; Shengdao Xiong; Kerry Hancock; Jinghua Yang; Zinta Harrington; Jingping Yang; Gregory Katsoulotos; Caiqing Zhang; Joshua Kim; Min Zhang; David Langton; Ping Zhang; Donald Lee; Wei Zhang; Matthew Peters; Xiaohe Zheng; Lakshman Prassad; Dan Zhu; Fabio Bolivar Grimaldos; Dimitar Sajkov; Alejandra Cañas Arboleda; Francis Santiago; Carlos Matiz Bueno; Frederick Graham Simpson; Dora Molina de Salazar; Sze Tai; Elisabeth Bendstrup; Paul Thomas; Ole Hilberg; Peter Wark; Carsten Kjellerup; José Eduardo Delfini Cançado; Ulla Weinreich; Thúlio Cunha; Philippe Bonniaud; Marina Lima; Olivier Brun; Alexandre Pinto Cardoso; Pierre-Régis Burgel; Marcelo Rabahi; Christos Chouaid; Syed Anees; Francis Couturaud; John Bertley; Jacques de Blic; Alan Bell; Didier Debieuvre; Amarjit Cheema; Dominique Delsart; Guy Chouinard; Axelle Demaegdt; Michael Csanadi; Anil Dhar; Antoine Deschildre; Ripple Dhillon; Gilles Devouassoux; Carole Egron; David Kanawaty; Lionel Falchero; Allan Kelly; François Goupil; William Killorn; Romain Kessler; Daniel Landry; Pascal Le Roux; Robert Luton; Pascal Mabire; Guillaume Mahay; Yumiko Ide; Stéphanie Martinez; Minehiko Inomata; Boris Melloni; Hiromasa Inoue; Laurent Moreau; Koji Inoue; Chantal Raherison; Sumito Inoue; Emilie Riviere; Motokazu Kato; Pauline Roux-Claudé; Masayuki Kawasaki; Michel Soulier; Tomotaka Kawayama; Guillaume Vignal; Toshiyuki Kita; Azzedine Yaici; Kanako Kobayashi; Sven Philip Aries; Hiroshi Koto; Robert Bals; Koichi Nishi; Ekkehard Beck; Junpei Saito; Andreas Deimling; Yasuo Shimizu; Jan Feimer; Toshihiro Shirai; Vera Grimm-Sachs; Naruhiko Sugihara; Gesine Groth; Ken-Ichi Takahashi; Felix Herth; Hiroyuki Tashimo; Gerhard Hoheisel; Keisuke Tomii; Frank Kanniess; Takashi Yamada; Thomas Lienert; Masaru Yanai; Silke Mronga; Ruth Cerino Javier; Jörg Reinhardt; Alfredo Domínguez Peregrina; Christian Schlenska; Marco Fernández Corzo; Christoph Stolpe; Efraín Montano Gonzalez; Ishak Teber; Alejandra Ramírez-Venegas; Hartmut Timmermann; Adrian Rendon; Thomas Ulrich; Willem Boersma; Peter Velling; R.S. Djamin; Sabina Wehgartner-Winkler; Michiel Eijsvogel; Juergen Welling; Frits Franssen; Ernst-Joachim Winkelmann; Martijn Goosens; Carlo Barbetta; Lidwien Graat-Verboom; Fulvio Braido; Johannes In 'T Veen; Vittorio Cardaci; Rob Janssen; Enrico Maria Clini; Kim Kuppens; Maria Teresa Costantino; Maarten van den Berge; Giuseppina Cuttitta; Mario van de Ven; Mario Di Gioacchino; Ole Petter Brunstad; Alessandro Fois; Gunnar Einvik; Maria Pia Foschino-Barbaro; Kristian Jong Høines; Enrico Gammeri; Alamdar Khusrawi; Riccardo Inchingolo; Torbjorn Oien; Federico Lavorini; Yoon-Seok Chang; Antonio Molino; Young Joo Cho; Eleonora Nucera; Yong Il Hwang; Alberto Papi; Woo Jin Kim; Vincenzo Patella; Young-Il Koh; Alberto Pesci; Byung-Jae Lee; Fabio Ricciardolo; Kwan-Ho Lee; Paola Rogliani; Sang-Pyo Lee; Riccardo Sarzani; Yong Chul Lee; Carlo Vancheri; Seong Yong Lim; Rigoletta Vincenti; Kyung Hun Min; Takeo Endo; Yeon-Mok Oh; Masaki Fujita; Choon-Sik Park; Yu Hara; Hae-Sim Park; Takahiko Horiguchi; Heung-Woo Park; Keita Hosoi; Chin Kook Rhee; Ho Joo Yoon; Alyn Morice; Hyoung-Kyu Yoon; Preeti Pandya; Alvar Agusti García-Navarro; Manish Patel; Rubén Andújar; Kay Roy; Laura Anoro; Ramamurthy Sathyamurthy; María Buendía García; Swaminathan Thiagarajan; Paloma Campo Mozo; Alice Turner; Sergio Campos; Jorgen Vestbo; Francisco Casas Maldonado; Wisia Wedzicha; Manuel Castilla Martínez; Tom Wilkinson; Carolina Cisneros Serrano; Pete Wilson; Lorena Comeche Casanova; Lo’ay Al-Asadi; Dolores Corbacho; James Anholm; Felix Del Campo Matías; Frank Averill; Jose Echave-Sustaeta; Sandeep Bansal; Gloria Francisco Corral; Alan Baptist; Pedro Gamboa Setién; Colin Campbell; Marta García Clemente; Michael A Campos; Ignacio García Núñez; Jose García Robaina; Gretchen Crook; Mercedes García Salmones; Samuel Deleon; Jose Maria Marín Trigo; Alain Eid; Marta Nuñez Fernandez; Ellen Epstein; Sara Nuñez Palomo; Stephen Fritz; Hoadley Harris; Luis Pérez de Llano; Mitzie Hewitt; Ana Pueyo Bastida; Fernando Holguin; Ana Rañó; Golda Hudes; José Rodríguez González-Moro; Richard Jackson; Albert Roger Reig; Alan Kaufman; José Velasco Garrido; David Kaufman; Dan Curiac; Ari Klapholz; Harshavardhan Krishna; Cornelia Lif-Tiberg; Daria Lee; Anders Luts; Robert Lin; Lennart Råhlen; Diego Maselli-Caceres; Stefan Rustscheff; Vinay Mehta; Frances Adams; James N Moy; Drew Bradman; Ugo Nwokoro; Emma Broughton; Purvi Parikh; John Cosgrove; Sudhir Parikh; Patrick Flood-Page; Frank Perrino; Elizabeth Fuller; James Ruhlmann; Catherine Sassoon; David Hartley; Russell A Settipane; Keith Hattotuwa; Daniel Sousa; Gareth Jones; Peruvemba Sriram; Keir Lewis; Richard Wachs; Lorcan Mcgarvey; José Olaguibel Rivera; Pascal Demoly

doi:10.1016/j.rmed.2022.106863

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The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study

Journal article

Open access

Peer reviewed

The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study

Sarowar Muhammad Golam, Christer Janson, Richard Beasley, J Mark Fitzgerald, Tim Harrison, Bradley Chipps, Rod Hughes, Hana Müllerová, José María Olaguibel, Eleni Rapsomaniki, …

Respiratory Medicine, Vol.200

09/05/2022

DOI: https://doi.org/10.1016/j.rmed.2022.106863

PMID: 35952579

Abstract

Disease burden

Healthcare resource utilisation

Longitudinal studies

Mild asthma

Patient-reported measures

Adrenal Cortex Hormones

Asthma

Disease Progression

Humans

Longitudinal Studies

Patient Acceptance of Health Care

Prospective Studies

Background: Patients with mild asthma represent a substantial proportion of the population with asthma, yet there are limited data on their true burden of disease. We aimed to describe the clinical and healthcare resource utilisation (HCRU) burden of physician-assessed mild asthma.Methods: Patients with mild asthma were included from the NOVEL observational longiTudinal studY (NOVELTY; NCT02760329), a global, 3-year, real-world prospective study of patients with asthma and/or chronic obstructive pulmonary disease from community practice (specialised and primary care). Diagnosis and severity were based on physician discretion. Clinical burden included physician-reported exacerbations and patient-reported measures. HCRU included inpatient and outpatient visits.Results: Overall, 2004 patients with mild asthma were included; 22.8% experienced ≥1 exacerbation in the previous 12 months, of whom 72.3% experienced ≥1 severe exacerbation. Of 625 exacerbations reported, 48.0% lasted >1 week, 27.7% were preceded by symptomatic worsening lasting >3 days, and 50.1% required oral corticosteroid treatment. Health status was moderately impacted (St George's Respiratory Questionnaire score: 23.5 [standard deviation ± 17.9]). At baseline, 29.7% of patients had asthma symptoms that were not well controlled or very poorly controlled (Asthma Control Test score <20), increasing to 55.6% for those with ≥2 exacerbations in the previous year. In terms of HCRU, at least one unscheduled ambulatory visit for exacerbations was required by 9.5% of patients, including 9.2% requiring ≥1 emergency department visit and 1.1% requiring ≥1 hospital admission.Conclusions: In this global sample representing community practice, a significant proportion of patients with physician-assessed mild asthma had considerable clinical burden and HCRU.

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Title: The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study
Creators - without role: Sarowar Muhammad Golam - AstraZeneca
Christer Janson - Uppsala University
Richard Beasley - Medical Research Institute of New Zealand
J Mark Fitzgerald - Vancouver General Hospital
Tim Harrison - Nottingham City Hospital
Bradley Chipps - Capital Allergy and Respiratory Disease Center
Rod Hughes - AstraZeneca
Hana Müllerová - AstraZeneca
José María Olaguibel - Complejo Hospitalario de Navarra
Eleni Rapsomaniki - AstraZeneca
Helen K Reddel - University of Sydney
Mohsen Sadatsafavi - University of British Columbia
Gabriel Benhabib
Piushkumar Mandhane
Xavier Bocca Ruiz
Andrew Mcivor
Ricardo Del Olmo
Bonavuth Pek
Raul Eduardo Lisanti
Robert Petrella
Gustavo Marino
Daniel Stollery
Walter Mattarucco
Meihua Chen
Juan Nogueira
Yan Chen
Maria Parody - Complejo Hospitalario de Navarra
Wei Gu - Complejo Hospitalario de Navarra
Pablo Pascale
Kim Ming Christopher Hui
Pablo Rodriguez
Manxiang Li
Damian Silva
Shiyue Li
Graciela Svetliza
Lijun Ma
Carlos F Victorio
Guangyue Qin
Roxana Willigs Rolon
Weidong Song
Anahi Yañez
Wei Tan
Stuart Baines
Yijun Tang
Simon Bowler
Chen Wang
Peter Bremner
Tan Wang
Sheetal Bull
Fuqiang Wen
Patrick Carroll
Feng Wu
Mariam Chaalan
Pingchao Xiang
Claude Farah
Zuke Xiao
Gary Hammerschlag
Shengdao Xiong
Kerry Hancock
Jinghua Yang
Zinta Harrington
Jingping Yang
Gregory Katsoulotos
Caiqing Zhang
Joshua Kim
Min Zhang
David Langton
Ping Zhang
Donald Lee
Wei Zhang
Matthew Peters
Xiaohe Zheng
Lakshman Prassad
Dan Zhu
Fabio Bolivar Grimaldos
Dimitar Sajkov
Alejandra Cañas Arboleda
Francis Santiago
Carlos Matiz Bueno
Frederick Graham Simpson
Dora Molina de Salazar
Sze Tai
Elisabeth Bendstrup
Paul Thomas
Ole Hilberg
Peter Wark
Carsten Kjellerup
José Eduardo Delfini Cançado
Ulla Weinreich
Thúlio Cunha
Philippe Bonniaud
Marina Lima
Olivier Brun
Alexandre Pinto Cardoso
Pierre-Régis Burgel
Marcelo Rabahi
Christos Chouaid
Syed Anees
Francis Couturaud
John Bertley
Jacques de Blic
Alan Bell
Didier Debieuvre
Amarjit Cheema
Dominique Delsart
Guy Chouinard
Axelle Demaegdt
Michael Csanadi
Anil Dhar
Antoine Deschildre
Ripple Dhillon
Gilles Devouassoux
Carole Egron
David Kanawaty
Lionel Falchero
Allan Kelly
François Goupil
William Killorn
Romain Kessler
Daniel Landry
Pascal Le Roux
Robert Luton
Pascal Mabire
Guillaume Mahay
Yumiko Ide
Stéphanie Martinez
Minehiko Inomata
Boris Melloni
Hiromasa Inoue
Laurent Moreau
Koji Inoue
Chantal Raherison
Sumito Inoue
Emilie Riviere
Motokazu Kato
Pauline Roux-Claudé
Masayuki Kawasaki
Michel Soulier
Tomotaka Kawayama
Guillaume Vignal
Toshiyuki Kita
Azzedine Yaici
Kanako Kobayashi
Sven Philip Aries
Hiroshi Koto
Robert Bals
Koichi Nishi
Ekkehard Beck
Junpei Saito
Andreas Deimling
Yasuo Shimizu
Jan Feimer - Uppsala University
Toshihiro Shirai
Vera Grimm-Sachs
Naruhiko Sugihara
Gesine Groth
Ken-Ichi Takahashi
Felix Herth
Hiroyuki Tashimo
Gerhard Hoheisel
Keisuke Tomii
Frank Kanniess
Takashi Yamada
Thomas Lienert
Masaru Yanai
Silke Mronga
Ruth Cerino Javier
Jörg Reinhardt
Alfredo Domínguez Peregrina
Christian Schlenska
Marco Fernández Corzo
Christoph Stolpe
Efraín Montano Gonzalez
Ishak Teber
Alejandra Ramírez-Venegas
Hartmut Timmermann
Adrian Rendon
Thomas Ulrich
Willem Boersma
Peter Velling
R.S. Djamin
Sabina Wehgartner-Winkler
Michiel Eijsvogel
Juergen Welling
Frits Franssen
Ernst-Joachim Winkelmann
Martijn Goosens
Carlo Barbetta
Lidwien Graat-Verboom
Fulvio Braido
Johannes In 'T Veen
Vittorio Cardaci
Rob Janssen
Enrico Maria Clini
Kim Kuppens
Maria Teresa Costantino
Maarten van den Berge
Giuseppina Cuttitta
Mario van de Ven
Mario Di Gioacchino
Ole Petter Brunstad
Alessandro Fois
Gunnar Einvik
Maria Pia Foschino-Barbaro
Kristian Jong Høines
Enrico Gammeri
Alamdar Khusrawi
Riccardo Inchingolo
Torbjorn Oien
Federico Lavorini
Yoon-Seok Chang
Antonio Molino
Young Joo Cho
Eleonora Nucera
Yong Il Hwang
Alberto Papi
Woo Jin Kim
Vincenzo Patella
Young-Il Koh
Alberto Pesci
Byung-Jae Lee
Fabio Ricciardolo
Kwan-Ho Lee
Paola Rogliani
Sang-Pyo Lee
Riccardo Sarzani
Yong Chul Lee
Carlo Vancheri
Seong Yong Lim
Rigoletta Vincenti
Kyung Hun Min
Takeo Endo
Yeon-Mok Oh
Masaki Fujita
Choon-Sik Park
Yu Hara
Hae-Sim Park
Takahiko Horiguchi
Heung-Woo Park
Keita Hosoi
Chin Kook Rhee
Ho Joo Yoon
Alyn Morice
Hyoung-Kyu Yoon
Preeti Pandya
Alvar Agusti García-Navarro
Manish Patel
Rubén Andújar
Kay Roy
Laura Anoro
Ramamurthy Sathyamurthy
María Buendía García
Swaminathan Thiagarajan
Paloma Campo Mozo
Alice Turner
Sergio Campos
Jorgen Vestbo
Francisco Casas Maldonado
Wisia Wedzicha
Manuel Castilla Martínez
Tom Wilkinson
Carolina Cisneros Serrano
Pete Wilson
Lorena Comeche Casanova
Lo’ay Al-Asadi
Dolores Corbacho
James Anholm
Felix Del Campo Matías
Frank Averill
Jose Echave-Sustaeta - Complejo Hospitalario de Navarra
Sandeep Bansal
Gloria Francisco Corral
Alan Baptist
Pedro Gamboa Setién
Colin Campbell
Marta García Clemente
Michael A Campos
Ignacio García Núñez
Jose García Robaina
Gretchen Crook
Mercedes García Salmones
Samuel Deleon
Jose Maria Marín Trigo
Alain Eid
Marta Nuñez Fernandez
Ellen Epstein
Sara Nuñez Palomo
Stephen Fritz
Hoadley Harris - Nottingham City Hospital
Luis Pérez de Llano
Mitzie Hewitt
Ana Pueyo Bastida
Fernando Holguin
Ana Rañó - AstraZeneca
Golda Hudes
José Rodríguez González-Moro
Richard Jackson - Medical Research Institute of New Zealand
Albert Roger Reig
Alan Kaufman
José Velasco Garrido
David Kaufman
Dan Curiac
Ari Klapholz - Complejo Hospitalario de Navarra
Harshavardhan Krishna
Cornelia Lif-Tiberg
Daria Lee
Anders Luts
Robert Lin
Lennart Råhlen
Diego Maselli-Caceres
Stefan Rustscheff
Vinay Mehta
Frances Adams
James N Moy
Drew Bradman
Ugo Nwokoro
Emma Broughton
Purvi Parikh
John Cosgrove
Sudhir Parikh
Patrick Flood-Page
Frank Perrino
Elizabeth Fuller
James Ruhlmann
Catherine Sassoon
David Hartley
Russell A Settipane
Keith Hattotuwa
Daniel Sousa
Gareth Jones
Peruvemba Sriram
Keir Lewis
Richard Wachs - Medical Research Institute of New Zealand
Lorcan Mcgarvey
José Olaguibel Rivera - Complejo Hospitalario de Navarra
Pascal Demoly - Centre Hospitalier Régional Universitaire [Montpellier]
Publication Details: Respiratory Medicine, Vol.200
Identifiers: 9937246809311
Academic Unit: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Language: English
Resource Type: Journal article
Local Fields: hal-03936613