The bonobo genome compared with the chimpanzee and human genomes

Kay Pruefer; Kasper Munch; Ines Hellmann; Keiko Akagi; Jason R. Miller; Brian Walenz; Sergey Koren; Granger Sutton; Chinnappa Kodira; Roger Winer; James R. Knight; James C. Mullikin; Stephen J. Meader; Chris P. Ponting; Gerton Lunter; Saneyuki Higashino; Asger Hobolth; Julien Dutheil; Emre Karakoc; Can Alkan; Saba Sajjadian; Claudia Rita Catacchio; Mario Ventura; Tomas Marques-Bonet; Evan E. Eichler; Claudine Andre; Rebeca Atencia; Lawrence Mugisha; Joerg Junhold; Nick Patterson; Michael Siebauer; Jeffrey M. Good; Anne Fischer; Susan E. Ptak; Michael Lachmann; David E. Symer; Thomas Mailund; Mikkel H. Schierup; Aida M. Andres; Janet Kelso; Svante Paeaebo

doi:10.1038/nature11128

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The bonobo genome compared with the chimpanzee and human genomes

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The bonobo genome compared with the chimpanzee and human genomes

Kay Pruefer, Kasper Munch, Ines Hellmann, Keiko Akagi, Jason R. Miller, Brian Walenz, Sergey Koren, Granger Sutton, Chinnappa Kodira, Roger Winer, …

Nature (London), Vol.486(7404), pp.527-531

28/06/2012

DOI: https://doi.org/10.1038/nature11128

PMID: 22722832

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours(1-4), and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other.

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Détails

Titre: The bonobo genome compared with the chimpanzee and human genomes
Créateurs - sans rôle: Kay Pruefer - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Kasper Munch - Aarhus University
Ines Hellmann - Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria
Keiko Akagi - Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA
Jason R. Miller - J Craig Venter Inst, Rockville, MD 20850 USA
Brian Walenz - J Craig Venter Inst, Rockville, MD 20850 USA
Sergey Koren - Univ Maryland, College Pk, MD 20742 USA
Granger Sutton - J Craig Venter Inst, Rockville, MD 20850 USA
Chinnappa Kodira - 454 Life Sci, Branford, CT 06405 USA
Roger Winer - 454 Life Sci, Branford, CT 06405 USA
James R. Knight - 454 Life Sci, Branford, CT 06405 USA
James C. Mullikin - NHGRI, Genome Technol Branch, Natl Inst Hlth, Bethesda, MD 20892 USA
Stephen J. Meader - Univ Oxford, Dept Physiol Anat & Genet, MRC Funct Genom Unit, Oxford OX1 3QX, England
Chris P. Ponting - Univ Oxford, Dept Physiol Anat & Genet, MRC Funct Genom Unit, Oxford OX1 3QX, England
Gerton Lunter - Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
Saneyuki Higashino - Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Kanagawa 2268503, Japan
Asger Hobolth - Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark
Julien Dutheil - Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark
Emre Karakoc - Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Can Alkan - Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Saba Sajjadian - Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Claudia Rita Catacchio - Univ Bari, Dipartimento Anat Patol & Genet, Sez Genet, I-70125 Bari, Italy
Mario Ventura - Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Tomas Marques-Bonet - Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Evan E. Eichler - Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Claudine Andre
Rebeca Atencia - Jane Goodall Inst, Pointe Noire, DEM REP CONGO
Lawrence Mugisha - CSWCT, Entebbe, Uganda
Joerg Junhold - Zoo Leipzig, D-04105 Leipzig, Germany
Nick Patterson - Harvard University
Michael Siebauer - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Jeffrey M. Good - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Anne Fischer - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Susan E. Ptak - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Michael Lachmann - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
David E. Symer - Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA
Thomas Mailund - Aarhus University
Mikkel H. Schierup - Aarhus University
Aida M. Andres - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Janet Kelso - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Svante Paeaebo - Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
Détails de publication: Nature (London), Vol.486(7404), pp.527-531
Éditeur: Springer Nature
Nombre de pages: 5
Note de subvention: 09-062535 / Danish Council for Independent Research \ Natural Sciences; Det Frie Forskningsrad (DFF) 233297 / European Research Council (ERC) ICREA OISE-0754461 / US National Science Foundation; National Science Foundation (NSF) 2R01GM077117-04A1; HG002385 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA PAS0425 / Ohio Supercomputer Center Ohio State University Comprehensive Cancer Center MC_U137761446 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 233297; StG_20091118 / ERC; European Research Council (ERC) Ramon y Cajal grant (MICINN-RYC); German Research Foundation (DFG)
Identifiants: 99159328409311
Unité académique: Institut des Sciences de l'Evolution - Montpellier - ISEM
Langue: English
Type de ressource: Journal article