The associations between biological markers of aging and appetite loss across adulthood: retrospective case–control data from the INSPIRE-T study

Annelie Turesson; Afsaneh Koochek; Margaretha Nydahl; Jean-Marc Lemaitre; Paul Bensadoun; Laurent O Martinez; Sophie Guyonnet; Yves Rolland; Bruno Vellas; Philipe de Souto Barreto; Lauréane Brigitte; Agathe Milhet; Elodie Paez; Emeline Muller; Sabine Le Floch; Catherine Takeda; Catherine Faisant; Françoise Lala; Gabor Abellan van Kan; Zara Steinmeyer; Antoine Piau; Tony Macaron; Davide Angioni; Pierre-Jean Ousset; Mélanie Comté; Nathalie Daniaud; Fanny Boissou-Parachaud; Sandrine Andrieu; Christelle Cantet; Fabien Pillard; Marie Faruch; Pierre Payoux; Neda Tavassoli; Marie Dorard; Bénédicte Razat; Camille Champigny; Cédric Dray; Jean-Philippe Pradère; Angelo Parini; Yohan Santin; Dominique Langin; Pierre Gourdy; Anne Bouloumié; Nicolas Fazilleau; Roland Liblau; Jean-Charles Guéry; Michel Simon; Nicolas Gaudenzio; Luciana Bostan; Hicham El Costa; Nabila Jabrane Ferrat; Philippe Valet; Isabelle Ader; Valérie Planat; Louis Casteilla; Patrice Peran; Cyrille Delpierre; Claire Rampon; Noelie Davezac; Bruno Guiard; Nathalie Vergnolle; Jean-Paul Motta; Sara Djebali; Pauline Floch; Céline Deraison; Chrystelle Bonnart; Jean-Emmanuel Sarry; Nicola Coley; Jessica Pontary

doi:10.1007/s11357-025-01691-w

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The associations between biological markers of aging and appetite loss across adulthood: retrospective case–control data from the INSPIRE-T study

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The associations between biological markers of aging and appetite loss across adulthood: retrospective case–control data from the INSPIRE-T study

Annelie Turesson, Afsaneh Koochek, Margaretha Nydahl, Jean-Marc Lemaitre, Paul Bensadoun, Laurent O Martinez, Sophie Guyonnet, Yves Rolland, Bruno Vellas, Philipe de Souto Barreto, …

GeroScience

10/05/2025

DOI: https://doi.org/10.1007/s11357-025-01691-w

Résumé

Biological aging

Longevity

Aging clocks

Anorexia of aging

Appetite loss is a common clinical condition in older adulthood, but how this condition associates with biological aging remains unknown. The present study aims to examine the associations of biological aging markers with appetite loss in community-dwelling people aged 21 to 102 years. This retrospective case-control study used baseline data from the INSPIRE-T cohort in Toulouse, France. Each of the 49 cases with appetite loss was sex-and age-matched to two controls without appetite loss (n = 147; median age of 79 years, interquartile range: 19.5; 67% women). Appetite loss was assessed using a single yes-no question from the World Health Organization´s Integrated Care for Older People screening tool. Biomarkers (first-and second-generation DNA methylation-based epigenetic clocks [Horvath, Hannum, PhenoAge, and GrimAge], the inflammatory aging clock iAge, and Adenosine triphosphatase inhibitory factor 1-IF1) were derived from blood samples. Logistic regression analyzed the associations of these markers with appetite loss. In fully adjusted models, accelerated aging using Grim-Age was the only biomarker associated with appetite loss (Odds Ratio = 1.21, 95% Confidence Interval: 1.03, 1.43). When stratified by age (≤ 65 years vs. > 65 years) and sex, this association remained significant only in individuals over 65 years and men. Future research is needed to explore the potential mechanisms involved, as well as how other biological drivers of aging (e.g., cell senescence, deregulated nutrient sensing) relate to appetite loss.

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Titre: The associations between biological markers of aging and appetite loss across adulthood: retrospective case–control data from the INSPIRE-T study
Créateurs - sans rôle: Annelie Turesson - Uppsala University
Afsaneh Koochek - Uppsala University
Margaretha Nydahl - Uppsala University
Jean-Marc Lemaitre - Université de Montpellier, Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Paul Bensadoun - Université de Montpellier, Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Laurent O Martinez - Inserm
Sophie Guyonnet - Université Fédérale de Toulouse Midi-Pyrénées
Yves Rolland - Inserm
Bruno Vellas - Institut de Mathématiques de Toulouse
Philipe de Souto Barreto - Institut de Mathématiques de Toulouse
Lauréane Brigitte - Institut Hospitalier Universitaire HealthAge
Agathe Milhet - Institut Hospitalier Universitaire HealthAge
Elodie Paez - Institut Hospitalier Universitaire HealthAge
Emeline Muller - Institut Hospitalier Universitaire HealthAge
Sabine Le Floch - Institut Hospitalier Universitaire HealthAge
Catherine Takeda - Institut Hospitalier Universitaire HealthAge
Catherine Faisant - Institut Hospitalier Universitaire HealthAge
Françoise Lala - Institut Hospitalier Universitaire HealthAge
Gabor Abellan van Kan - Institut Hospitalier Universitaire HealthAge
Zara Steinmeyer - Institut Hospitalier Universitaire HealthAge
Antoine Piau - Institut Hospitalier Universitaire HealthAge
Tony Macaron - Institut Hospitalier Universitaire HealthAge
Davide Angioni - Institut Hospitalier Universitaire HealthAge
Pierre-Jean Ousset - Institut Hospitalier Universitaire HealthAge
Mélanie Comté - Institut Hospitalier Universitaire HealthAge
Nathalie Daniaud - Institut Hospitalier Universitaire HealthAge
Fanny Boissou-Parachaud - Institut Hospitalier Universitaire HealthAge
Sandrine Andrieu - Institut Hospitalier Universitaire HealthAge
Christelle Cantet - Institut Hospitalier Universitaire HealthAge
Fabien Pillard - Institut Hospitalier Universitaire HealthAge
Marie Faruch - Institut Hospitalier Universitaire HealthAge
Pierre Payoux - Institut Hospitalier Universitaire HealthAge
Catherine Takeda - Institut Hospitalier Universitaire HealthAge
Neda Tavassoli - Institut Hospitalier Universitaire HealthAge
Marie Dorard - Institut Hospitalier Universitaire HealthAge
Bénédicte Razat - Institut Hospitalier Universitaire HealthAge
Camille Champigny - Institut Hospitalier Universitaire HealthAge
Cédric Dray - Institut Hospitalier Universitaire HealthAge
Jean-Philippe Pradère - Institut Hospitalier Universitaire HealthAge
Angelo Parini - Institut Hospitalier Universitaire HealthAge
Yohan Santin - Institut Hospitalier Universitaire HealthAge
Dominique Langin - Institut Hospitalier Universitaire HealthAge
Pierre Gourdy - Institut Hospitalier Universitaire HealthAge
Anne Bouloumié - Institut Hospitalier Universitaire HealthAge
Nicolas Fazilleau - Institut Hospitalier Universitaire HealthAge
Roland Liblau - Institut Hospitalier Universitaire HealthAge
Jean-Charles Guéry - Institut Hospitalier Universitaire HealthAge
Michel Simon - Institut Hospitalier Universitaire HealthAge
Nicolas Gaudenzio - Institut Hospitalier Universitaire HealthAge
Luciana Bostan - Institut Hospitalier Universitaire HealthAge
Hicham El Costa - Institut Hospitalier Universitaire HealthAge
Nabila Jabrane Ferrat - Institut Hospitalier Universitaire HealthAge
Philippe Valet - Institut Hospitalier Universitaire HealthAge
Isabelle Ader - Institut Hospitalier Universitaire HealthAge
Valérie Planat - Institut Hospitalier Universitaire HealthAge
Louis Casteilla - Institut Hospitalier Universitaire HealthAge
Patrice Peran - Institut Hospitalier Universitaire HealthAge
Cyrille Delpierre - Institut Hospitalier Universitaire HealthAge
Claire Rampon - Institut Hospitalier Universitaire HealthAge
Noelie Davezac - Institut Hospitalier Universitaire HealthAge
Bruno Guiard - Institut Hospitalier Universitaire HealthAge
Nathalie Vergnolle - Institut Hospitalier Universitaire HealthAge
Jean-Paul Motta - Institut Hospitalier Universitaire HealthAge
Sara Djebali - Institut Hospitalier Universitaire HealthAge
Pauline Floch - Institut Hospitalier Universitaire HealthAge
Céline Deraison - Institut Hospitalier Universitaire HealthAge
Chrystelle Bonnart - Institut Hospitalier Universitaire HealthAge
Jean-Emmanuel Sarry - Institut Hospitalier Universitaire HealthAge
Nicola Coley - Institut Hospitalier Universitaire HealthAge
Jessica Pontary - Institut Hospitalier Universitaire HealthAge
Détails de publication: GeroScience
Note de subvention: Swedish Research Council (2022–06295) and Crown Princess Margaret Foundation
Identifiants: 99151117209311
Unité académique: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Langue: English
Type de ressource: Journal article
Champs locaux: hal-05065187