The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA

Jesse Rabinowitz; Isabelle Vila; Charlotte Luchsinger; Cinzia Bertelli; Moritz Schüssler; Clara Taffoni; Bin Cui; Annie Zhi Dai; Mohammad Rashid; William Cisneros; Daphne Cornish; Juan Redondo; Kathryn Jackson-Jones; Lacy Simons; Ramon Lorenzo-Redondo; Nadine Laguette; Judd Hultquist; Felipe Diaz-Griffero

doi:10.1016/j.jbc.2025.110430

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The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA

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The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA

Jesse Rabinowitz, Isabelle Vila, Charlotte Luchsinger, Cinzia Bertelli, Moritz Schüssler, Clara Taffoni, Bin Cui, Annie Zhi Dai, Mohammad Rashid, William Cisneros, …

Journal of Biological Chemistry, Vol.301(8)

08/2025

DOI: https://doi.org/10.1016/j.jbc.2025.110430

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Titre: The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA
Créateurs - sans rôle: Jesse Rabinowitz - Albert Einstein College of Medicine
Isabelle Vila - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Charlotte Luchsinger - Albert Einstein College of Medicine
Cinzia Bertelli - Albert Einstein College of Medicine
Moritz Schüssler - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Clara Taffoni - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Bin Cui - Albert Einstein College of Medicine
Annie Zhi Dai
Mohammad Rashid - Albert Einstein College of Medicine
William Cisneros - Northwestern University
Daphne Cornish - Northwestern University
Juan Redondo - Albert Einstein College of Medicine
Kathryn Jackson-Jones - Northwestern University
Lacy Simons - Northwestern University
Ramon Lorenzo-Redondo - Northwestern University
Nadine Laguette - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Judd Hultquist - Northwestern University
Felipe Diaz-Griffero - Albert Einstein College of Medicine
Détails de publication: Journal of Biological Chemistry, Vol.301(8)
Identifiants: 99129694609311
Unité académique: Institut de Génétique Moléculaire de Montpellier - IGMM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-05362503