The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons

Frédéric Marmigère; Andreas Montelius; Michael Wegner; Yoram Groner; Louis F Reichardt; Patrik Ernfors

doi:10.1038/nn1631

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The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons

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The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons

Frédéric Marmigère, Andreas Montelius, Michael Wegner, Yoram Groner, Louis F Reichardt et Patrik Ernfors

Nature neuroscience, Vol.9(2), pp.180-187

01/02/2006

DOI: https://doi.org/10.1038/nn1631

PMID: 16429136

Résumé

Neural crest cells (NCCs) can adopt different neuronal fates. In NCCs, neurogenin-2 promotes sensory specification but does not specify different subclasses of sensory neurons. Understanding the gene cascades that direct Trk gene activation may reveal mechanisms generating sensory diversity, because different Trks are expressed in different sensory neuron subpopulations. Here we show in chick and mouse that the Runt transcription factor Runx1 promotes axonal growth, is selectively expressed in neural crest-derived TrkA+ sensory neurons and mediates TrkA transactivation in migratory NCCs. Inhibition of Runt activity depletes TrkA expression and leads to neuronal death. Moreover, Runx1 overexpression is incompatible with multipotency in the migratory neural crest but does not induce expression of pan-neuronal genes. Instead, Runx1-induced neuronal differentiation depends on an existing neurogenin2 proneural gene program. Our data show that Runx1 directs, in a context-dependent manner, key aspects of the establishment of the TrkA+ nociceptive subclass of neurons.

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Titre: The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons
Créateurs - sans rôle: Frédéric Marmigère - Laboratory of Molecular Neurobiology, Karolinska Institute, MBB, Scheeles väg 1, Stockholm, Sweden Institute of Biochemistry, Friedrich-Alexander-University, Erlangen-Nurnberg, Erlangen 91054, Germany Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel Howard Hughes Medical Institute and Department of Physiology, University of California San Francisco, San Francisco, California 94143, USA
Andreas Montelius - Laboratory of Molecular Neurobiology, Karolinska Institute, MBB, Scheeles väg 1, Stockholm, Sweden Institute of Biochemistry, Friedrich-Alexander-University, Erlangen-Nurnberg, Erlangen 91054, Germany Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel Howard Hughes Medical Institute and Department of Physiology, University of California San Francisco, San Francisco, California 94143, USA
Michael Wegner - Friedrich-Alexander-Universität Erlangen-Nürnberg
Yoram Groner - Laboratory of Molecular Neurobiology, Karolinska Institute, MBB, Scheeles väg 1, Stockholm, Sweden Institute of Biochemistry, Friedrich-Alexander-University, Erlangen-Nurnberg, Erlangen 91054, Germany Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel Howard Hughes Medical Institute and Department of Physiology, University of California San Francisco, San Francisco, California 94143, USA
Louis F Reichardt - Laboratory of Molecular Neurobiology, Karolinska Institute, MBB, Scheeles väg 1, Stockholm, Sweden Institute of Biochemistry, Friedrich-Alexander-University, Erlangen-Nurnberg, Erlangen 91054, Germany Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel Howard Hughes Medical Institute and Department of Physiology, University of California San Francisco, San Francisco, California 94143, USA
Patrik Ernfors - Laboratory of Molecular Neurobiology, Karolinska Institute, MBB, Scheeles väg 1, Stockholm, Sweden Institute of Biochemistry, Friedrich-Alexander-University, Erlangen-Nurnberg, Erlangen 91054, Germany Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel Howard Hughes Medical Institute and Department of Physiology, University of California San Francisco, San Francisco, California 94143, USA
Détails de publication: Nature neuroscience, Vol.9(2), pp.180-187
Nombre de pages: 8
Identifiants: 99140119209311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article