The Mouse FusedLocus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Li Zeng; François Fagotto; Tong Zhang; Wei Hsu; Thomas J Vasicek; William L Perry; James J Lee; Shirley M Tilghman; Barry M Gumbiner; Frank Costantini

doi:10.1016/S0092-8674(00)80324-4

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The Mouse FusedLocus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

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The Mouse FusedLocus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Li Zeng, François Fagotto, Tong Zhang, Wei Hsu, Thomas J Vasicek, William L Perry, James J Lee, Shirley M Tilghman, Barry M Gumbiner et Frank Costantini

Cell, Vol.90(1), pp.181-192

1997

DOI: https://doi.org/10.1016/S0092-8674(00)80324-4

Résumé

Mutations at the mouse Fused locus have pleiotropic developmental effects, including the formation of axial duplications in homozygous embryos. The product of the Fused locus, Axin, displays similarities to RGS ( R egulators of G -Protein S ignaling) and Dishevelled proteins. Mutant Fused alleles that cause axial duplications disrupt the major mRNA, suggesting that Axin negatively regulates the response to an axis-inducing signal. Injection of Axin mRNA into Xenopus embryos inhibits dorsal axis formation by interfering with signaling through the Wnt pathway. Furthermore, ventral injection of an Axin mRNA lacking the RGS domain induces an ectopic axis, apparently through a dominant-negative mechanism. Thus, Axin is a novel inhibitor of Wnt signaling and regulates an early step in embryonic axis formation in mammals and amphibians.

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Titre: The Mouse FusedLocus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation
Créateurs - sans rôle: Li Zeng - Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
François Fagotto - Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Tong Zhang - Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Wei Hsu - Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Thomas J Vasicek - Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
William L Perry - Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
James J Lee - Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Shirley M Tilghman - Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
Barry M Gumbiner - Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Frank Costantini - Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Détails de publication: Cell, Vol.90(1), pp.181-192
Éditeur: Elsevier Inc
Identifiants: 99136514909311
Unité académique: Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Langue: English
Type de ressource: Journal article