The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

Ian A. Graham; Katrin Besser; Susan Blumer; Caroline A. Branigan; Tomasz Czechowski; Luisa Elias; Inna Guterman; David Harvey; Peter G. Isaac; Awais M. Khan; Tony R. Larson; Yi Li; Tanya Pawson; Teresa Penfield; Anne M. Rae; Deborah A. Rathbone; Sonja Reid; Joe Ross; Margaret F. Smallwood; Vincent Segura; Theresa Townsend; Darshna Vyas; Thilo Winzer; Dianna Bowles

doi:10.1126/science.1182612

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The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

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The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

Ian A. Graham, Katrin Besser, Susan Blumer, Caroline A. Branigan, Tomasz Czechowski, Luisa Elias, Inna Guterman, David Harvey, Peter G. Isaac, Awais M. Khan, …

Science (American Association for the Advancement of Science), Vol.327(5963), pp.328-331

15/01/2010

DOI: https://doi.org/10.1126/science.1182612

PMID: 20075252

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Artemisinin is a plant natural product produced by Artemisia annua and the active ingredient in the most effective treatment for malaria. Efforts to eradicate malaria are increasing demand for an affordable, high-quality, robust supply of artemisinin. We performed deep sequencing on the transcriptome of A. annua to identify genes and markers for fast-track breeding. Extensive genetic variation enabled us to build a detailed genetic map with nine linkage groups. Replicated field trials resulted in a quantitative trait loci (QTL) map that accounts for a significant amount of the variation in key traits controlling artemisinin yield. Enrichment for positive QTLs in parents of new high-yielding hybrids confirms that the knowledge and tools to convert A. annua into a robust crop are now available.

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Titre: The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin
Créateurs - sans rôle: Ian A. Graham - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Katrin Besser - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Susan Blumer - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Caroline A. Branigan - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Tomasz Czechowski - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Luisa Elias - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Inna Guterman - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
David Harvey - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Peter G. Isaac - IDna Genet Ltd, Norwich NR4 7UH, Norfolk, England
Awais M. Khan - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Tony R. Larson - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Yi Li - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Tanya Pawson - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Teresa Penfield - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Anne M. Rae - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Deborah A. Rathbone - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Sonja Reid - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Joe Ross - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Margaret F. Smallwood - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Vincent Segura - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Theresa Townsend - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Darshna Vyas - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Thilo Winzer - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Dianna Bowles - Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England
Détails de publication: Science (American Association for the Advancement of Science), Vol.327(5963), pp.328-331
Éditeur: Amer Assoc Advancement Science
Nombre de pages: 4
Note de subvention: Garfield Weston Foundation for the Centre for Novel Agricultural Products Medicines for Malaria Venture Bill and Melinda Gates Foundation; Bill & Melinda Gates Foundation
Identifiants: 99163895609311
Unité académique: Institut Amélioration Génétique & Adaptation des Plantes méditerranéennes & tropicales-AGAP
Langue: English
Type de ressource: Journal article