The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery

Laura Videla; Bessy Benejam; Isabel Barroeta; Susana Fernandez; Miren Altuna; Javier Arranz; Íñigo Rodríguez-Baz; José Enrique Arriola-Infante; Lucía Maure-Blesa; Laura Del Hoyo Soriano; Ignacio Illán-Gala; Teresa Estellés; Aida Sanjuan; Lídia Vaqué-Alcázar; Mateus Rozalem Aranha; Alejandra O Morcillo-Nieto; Sarah Erzsebet Zsadanyi; Maria Franquesa-Mullerat; Sílvia Valldeneu; María Belén Sánchez-Saudinós; Concepción Padilla; Mireia Carreras; Oriol Lorente; Natalia Valle-Tamayo; Érika Sánchez-Aced; Oriol Dols-Icardo; Sònia Sirisi; Laia Muñoz; Soraya Torres; Shaima El Bounasr El Bennadi; Oriol Sánchez; Diana Garzón; Laia Ribas; Sumia Elbachiri; Cecilia Mota; Mireia Tondo; Valle Camacho; Sandra Giménez; Constance Delaby; Olivia Belbin; María Florencia Iulita; Víctor Montal; Jordi Pegueroles; Eduard Vilaplana; Jordi Clarimón; Sofía González-Ortiz; Laura Molina-Porcel; Iban Aldecoa; Daniel Alcolea; Alexandre Bejanin; Sebastià Videla; Rafael Blesa; Alberto Lleó; María Carmona-Iragui; Juan Fortea

doi:10.1002/alz.70259

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The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery

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The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery

Laura Videla, Bessy Benejam, Isabel Barroeta, Susana Fernandez, Miren Altuna, Javier Arranz, Íñigo Rodríguez-Baz, José Enrique Arriola-Infante, Lucía Maure-Blesa, Laura Del Hoyo Soriano, …

Alzheimer's & dementia, Vol.21(6), pp.e70259-n/a

06/2025

DOI: https://doi.org/10.1002/alz.70259

PMID: 40528282

Résumé

Adult

Alzheimer Disease - diagnostic imaging

Biomarkers

Cohort Studies

Disease Progression

Down Syndrome - complications

Down Syndrome - diagnostic imaging

Female

Humans

Male

Middle Aged

Neuroimaging

Neuropsychological Tests

Down syndrome (DS) is a genetic form of Alzheimer's disease (AD) that offers crucial insights into AD pathogenesis. The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) is a population-based multimodal biomarker cohort studying AD's natural history and clinical trials in DS. DABNI included 1135 participants (mean age 42.82, 46.3% female). At baseline, 673 participants were cognitively stable, 113 had prodromal AD, 239 had AD dementia, and 110 were uncertain due to non-AD conditions. Over 10 years, > 10000 clinical visits were conducted; follow-up showed that progression to symptomatic AD before age 40 was rare, but rates increased after age 50 (> 50% within 5 years). Neuropsychological and biomarker assessments demonstrated excellent diagnostic performance and a predictable sequence of changes, similar to autosomal dominant AD. DABNI participates in AD clinical trials and produced approximately 100 publications. The 10-year DABNI study provided critical insights into DS-associated AD (DSAD) and serves as a key platform for DS clinical trials. HIGHLIGHTS: Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) is a population-based multimodal cohort studying Alzheimer's disease in Down syndrome. Over 10 years, 1135 participants contributed to more than 10000 clinical visits and extensive biomarker studies. DABNI findings have transformed the understanding of Alzheimer's disease in Down syndrome, reinforcing its classification as a genetic form of the disease. The cohort integrates clinical care and research, enhancing early detection and patient management. DABNI supports clinical trials and has produced over 100 publications advancing Down syndrome-related Alzheimer's research.

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Titre: The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery
Créateurs - sans rôle: Laura Videla - Centro de Investigación Biomédica en Red
Bessy Benejam - Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain
Isabel Barroeta - Centro de Investigación Biomédica en Red
Susana Fernandez - Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain
Miren Altuna - CITA-alzheimer foundation, Paseo Mikeletegi, Donostia-San Sebastián, Spain
Javier Arranz - Hospital de Sant Pau
Íñigo Rodríguez-Baz - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
José Enrique Arriola-Infante - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Lucía Maure-Blesa - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Laura Del Hoyo Soriano - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Ignacio Illán-Gala - Centro de Investigación Biomédica en Red
Teresa Estellés - Centro de Investigación Biomédica en Red
Aida Sanjuan - Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Lídia Vaqué-Alcázar - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain
Mateus Rozalem Aranha - Hospital de Sant Pau
Alejandra O Morcillo-Nieto - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Sarah Erzsebet Zsadanyi - Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Maria Franquesa-Mullerat - Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Sílvia Valldeneu - Centro de Investigación Biomédica en Red
María Belén Sánchez-Saudinós - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Concepción Padilla - Universitat Oberta de Catalunya
Mireia Carreras - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Oriol Lorente - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Natalia Valle-Tamayo - Centro de Investigación Biomédica en Red
Érika Sánchez-Aced - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Oriol Dols-Icardo - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Sònia Sirisi - Centro de Investigación Biomédica en Red
Laia Muñoz - Centro de Investigación Biomédica en Red
Soraya Torres - Centro de Investigación Biomédica en Red
Shaima El Bounasr El Bennadi - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Oriol Sánchez - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Diana Garzón - Hospital de Sant Pau
Laia Ribas - Hospital de Sant Pau
Sumia Elbachiri - Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Cecilia Mota - Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Mireia Tondo - Hospital de Sant Pau
Valle Camacho - Hospital de Sant Pau
Sandra Giménez - Hospital de Sant Pau
Constance Delaby - Université de Montpellier
Olivia Belbin - Centro de Investigación Biomédica en Red
María Florencia Iulita - Altoida Inc., Washington, District of Columbia, USA
Víctor Montal - Barcelona Supercomputing Center
Jordi Pegueroles - Hospital de Sant Pau
Eduard Vilaplana - Hospital de Sant Pau
Jordi Clarimón - H Lundbeck A/S, Valby, Denmark
Sofía González-Ortiz - Hospital Del Mar
Laura Molina-Porcel - Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain
Iban Aldecoa - Pathology Department, Biomedical Diagnostic Center, Hospital Clinic de Barcelona-University of Barcelona, Barcelona, Spain
Daniel Alcolea - Centro de Investigación Biomédica en Red
Alexandre Bejanin - Centro de Investigación Biomédica en Red
Sebastià Videla - Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Bellaterra, Spain
Rafael Blesa - Centro de Investigación Biomédica en Red
Alberto Lleó - Centro de Investigación Biomédica en Red
María Carmona-Iragui - Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Juan Fortea - Centro de Investigación Biomédica en Red
Détails de publication: Alzheimer's & dementia, Vol.21(6), pp.e70259-n/a
Note de subvention: PI18/00335 / Instituto de Salud Carlos III (Ministerio de Ciencia, Innovación y Universidades, Gobierno de España) IIBSP-DOW-2020-151 / Fundación Tatiana Pérez de Guzmán el Bueno R61AG066543 / NIH HHS CP20/00038 / Instituto de Salud Carlos III through the Miguel Servet Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, Una Manera de Hacer Europa CM22/00219 / Instituto de Salud Carlos III through the Río Hortega Fellowship PDC-2023-51 / Fondation Jérôme Lejeune AARG-22-923680 / Alzheimer's Association #1913cycle2019B / Fondation Jérôme Lejeune PI22/00611 / Instituto de Salud Carlos III (Ministerio de Ciencia, Innovación y Universidades, Gobierno de España)
Identifiants: 99139852109311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article