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Tetra vs. octa - How it affects the photophysical, photochemical, physicochemical and biological properties of mercaptophenol-substituted Zn phthalocyanines
Journal article   Peer reviewed

Tetra vs. octa - How it affects the photophysical, photochemical, physicochemical and biological properties of mercaptophenol-substituted Zn phthalocyanines

Derya Topkaya, Derya Aydın, Haifa Ben Aziza, Zeynel Şahin, Ümit Isci, Denis Durand, Uygar Tazebay, Magali Gary-Bobo and Fabienne Dumoulin
Journal of Porphyrins and Phthalocyanines, Vol.26(11), pp.701-707
08/11/2022

Abstract

Phthalocyanine mercaptophenol singlet oxygen generation photodynamic therapy in vitro
Zn phthalocyanines tetra- and octa- substituted in peripheral positions by mercaptophenol moieties were prepared. Photophysical, photochemical, physicochemical and biological properties relevant from a photodynamic therapy point of view have been determined, showing that the tetra-substituted derivatives have better potential, confirmed by in vitro tests performed on MCF-7 cells that induced significant cell death without showing dark toxicity.
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