Targeting of the Virulence Factor Acetohydroxyacid Synthase by Sulfonylureas Results in Inhibition of Intramacrophagic Multiplication of Brucella suis

Rose-Anne Boigegrain; Jean-Pierre Liautard; Stephan Köhler

doi:10.1128/AAC.49.9.3922-3925.2005

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Targeting of the Virulence Factor Acetohydroxyacid Synthase by Sulfonylureas Results in Inhibition of Intramacrophagic Multiplication of Brucella suis

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Targeting of the Virulence Factor Acetohydroxyacid Synthase by Sulfonylureas Results in Inhibition of Intramacrophagic Multiplication of Brucella suis

Rose-Anne Boigegrain, Jean-Pierre Liautard et Stephan Köhler

Antimicrobial agents and chemotherapy, Vol.49(9), pp.3922-3925

01/09/2005

DOI: https://doi.org/10.1128/AAC.49.9.3922-3925.2005

PMID: 16127072

Résumé

Acetolactate Synthase

Brucella suis

Macrophages

Mechanisms of Action: Physiological Effects

Sulfonylurea Compounds

Virulence Factors

The acetohydroxyacid synthase (AHAS) of Brucella suis can be effectively targeted by the sulfonylureas chlorimuron ethyl and metsulfuron methyl. Growth in minimal medium was inhibited, and multiplication in human macrophages was totally abolished with 100 μM of sulfonylureas. Metsulfuron methyl-resistant mutants showed reduced viability in macrophages and reduced AHAS activity.

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Détails

Titre: Targeting of the Virulence Factor Acetohydroxyacid Synthase by Sulfonylureas Results in Inhibition of Intramacrophagic Multiplication of Brucella suis
Créateurs - sans rôle: Rose-Anne Boigegrain - Institut National de la Santé et de la Recherche Médicale U-431, Université Montpellier II, Pl. E. Bataillon, 34095 Montpellier, France
Jean-Pierre Liautard - Institut National de la Santé et de la Recherche Médicale U-431, Université Montpellier II, Pl. E. Bataillon, 34095 Montpellier, France
Stephan Köhler - Institut National de la Santé et de la Recherche Médicale U-431, Université Montpellier II, Pl. E. Bataillon, 34095 Montpellier, France
Détails de publication: Antimicrobial agents and chemotherapy, Vol.49(9), pp.3922-3925
Éditeur: American Society for Microbiology
Nombre de pages: 4
Identifiants: 99155332609311
Unité académique: Institut de Recherche en Infectiologie de Montpellier - IRIM
Langue: English
Type de ressource: Journal article