Systems medicine and integrated care to combat chronic noncommunicable diseases

Jean Bousquet; Josep M. Anto; Peter J. Sterk; Ian M. Adcock; Kian Fan Chung; Josep Roca; Alvar Agusti; Chris Brightling; Anne Cambon-Thomsen; Alfredo Cesario; Sonia Abdelhak; Stylianos E. Antonarakis; Antoine Avignon; Andrea Ballabio; Eugenio Baraldi; Alexander Baranov; Thomas Bieber; Joël Bockaert; Samir Brahmachari; Christian Brambilla; Jacques Bringer; Michel Dauzat; Ingemar Ernberg; Leonardo Fabbri; Philippe Froguel; David Galas; Takashi Gojobori; Peter Hunter; Christian Jorgensen; Francine Kauffmann; Philippe Kourilsky; Marek L. Kowalski; Doron Lancet; Claude Le Pen; Jacques Mallet; Bongani Mayosi; Jacques Mercier; Andres Metspalu; Joseph H. Nadeau; Gregory Ninot; Denis Noble; Mehmet Ozturk; Susanna Palkonen; Christian Préfaut; Klaus Rabe; Eric Renard; Richard G. Roberts; Boleslav Samolinski; Holger J. Schuenemann; Hans-Uwe Simon; Marcelo Bento Soares; Giulio Superti-Furga; Jesper Tegnér; Sergio Verjovski-Almeida; Peter Wellstead; Olaf Wolkenhauer; Emiel Wouters; Rudi Balling; Anthony J. Brookes; Dominique Charron; Christophe Pison; Zhu Chen; Leroy Hood; Charles Auffray

doi:10.1186/gm259

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Systems medicine and integrated care to combat chronic noncommunicable diseases

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Systems medicine and integrated care to combat chronic noncommunicable diseases

Jean Bousquet, Josep M. Anto, Peter J. Sterk, Ian M. Adcock, Kian Fan Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, …

Genome Medicine, Vol.3

2011

DOI: https://doi.org/10.1186/gm259

Abstract

We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specic complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specicities of local economies and health systems.

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Title: Systems medicine and integrated care to combat chronic noncommunicable diseases
Creators - without role: Jean Bousquet - Inserm
Josep M. Anto - Pompeu Fabra University
Peter J. Sterk - University of Amsterdam
Ian M. Adcock - Imperial College London
Kian Fan Chung - Imperial College London
Josep Roca - Universitat de Barcelona
Alvar Agusti - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Chris Brightling
Anne Cambon-Thomsen - Inserm
Alfredo Cesario - IRCCS Ospedale San Raffaele
Sonia Abdelhak - Institut Pasteur de Tunis
Stylianos E. Antonarakis - University of Geneva
Antoine Avignon - Centre Hospitalier Universitaire de Montpellier
Andrea Ballabio - Telethon Institute Of Genetics And Medicine
Eugenio Baraldi - University of Padua
Alexander Baranov
Thomas Bieber - University of Bonn
Joël Bockaert - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Samir Brahmachari - Institute of Genomics and Integrative Biology
Christian Brambilla - Institut pour l'avancée des biosciences
Jacques Bringer - Hôpital Lapeyronie
Michel Dauzat - Université de Nîmes
Ingemar Ernberg - Karolinska Institutet
Leonardo Fabbri - University of Modena and Reggio Emilia
Philippe Froguel - Imperial College London
David Galas - North Seattle College
Takashi Gojobori - National Institute of Genetics
Peter Hunter - University of Auckland
Christian Jorgensen - Cellules souches mésenchymateuses, environnement articulaire et immunothérapies de la polyarthrite rhumatoide
Francine Kauffmann - Inserm
Philippe Kourilsky - Singapore Immunology Network
Marek L. Kowalski - Medical University of Lodz
Doron Lancet - Weizmann Institute of Science
Claude Le Pen - Université Paris Dauphine-PSL
Jacques Mallet - Institut de Radiobiologie Cellulaire et Moléculaire
Bongani Mayosi - University of Cape Town
Jacques Mercier - Inserm
Andres Metspalu - University of Tartu
Joseph H. Nadeau - North Seattle College
Gregory Ninot - Dynamique des Capacités Humaines et des Conduites de Santé
Denis Noble - University of Oxford
Mehmet Ozturk - Bilkent University
Susanna Palkonen - European Federation of Allergy and Airways Diseases Patients Associations
Christian Préfaut - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Klaus Rabe - Kiel University
Eric Renard - Hôpital Lapeyronie
Richard G. Roberts - University of Wisconsin–Madison
Boleslav Samolinski
Holger J. Schuenemann
Hans-Uwe Simon
Marcelo Bento Soares - Northwestern University
Giulio Superti-Furga - Directors's Laboratory
Jesper Tegnér - Karolinska Institutet
Sergio Verjovski-Almeida - Universidade de São Paulo
Peter Wellstead - National University of Ireland, Maynooth
Olaf Wolkenhauer - University of Rostock
Emiel Wouters
Rudi Balling - University of Luxembourg
Anthony J. Brookes - University of Leicester
Dominique Charron - Inserm
Christophe Pison - European Institute for Systems Biology and Medicine
Zhu Chen
Leroy Hood - Institute for Systems Biology
Charles Auffray - European Institute for Systems Biology and Medicine
Publication Details: Genome Medicine, Vol.3
Identifiers: 9936898109311
Academic Unit: Institut de Génomique Fonctionnelle - IGF; Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: hal-01358549