Systemic Inflammatory Response Syndrome, Thromboinflammation, and Septic Shock in Fetuses and Neonates

Victoria Bitsadze; Arina Lazarchuk; Alexander Vorobev; Jamilya Khizroeva; Maria Tretyakova; Natalia Makatsariya; Nilufar Gashimova; Kristina Grigoreva; Alena Tatarintseva; Anna Karpova; Aleksei Mostovoi; Marina Zainulina; Daredzhan Kapanadze; Armen Blbulyan; Nart Kuneshko; Jean-Christophe Gris; Ismail Elalamy; Grigoris Gerotziafas; Alexander Makatsariya

doi:10.3390/ijms26073259

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Systemic Inflammatory Response Syndrome, Thromboinflammation, and Septic Shock in Fetuses and Neonates

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Systemic Inflammatory Response Syndrome, Thromboinflammation, and Septic Shock in Fetuses and Neonates

Victoria Bitsadze, Arina Lazarchuk, Alexander Vorobev, Jamilya Khizroeva, Maria Tretyakova, Natalia Makatsariya, Nilufar Gashimova, Kristina Grigoreva, Alena Tatarintseva, Anna Karpova, …

International journal of molecular sciences, Vol.26(7), p.3259

01/04/2025

DOI: https://doi.org/10.3390/ijms26073259

PMID: 40244141

Résumé

Biomarkers

Female

Fetus - pathology

Humans

Infant, Newborn

Pregnancy

Shock, Septic - diagnosis

Shock, Septic - etiology

Systemic Inflammatory Response Syndrome - diagnosis

Thromboinflammation - diagnosis

This article explores systemic inflammatory response syndrome (SIRS), thromboinflammation, and septic shock in fetuses and neonates, offering a comprehensive examination of their pathophysiology, diagnostic criteria, and clinical implications. It identifies SIRS as an exaggerated response to external stress, disrupting the balance between inflammation and adaptive mechanisms, driven by cytokines such as TNF-α and IL-1. The fetal inflammatory response syndrome (FIRS), a subset of SIRS, is noted for its role in adverse neonatal outcomes, including organ damage, inflammation, and long-term developmental disorders. The article discusses the extensive effects of FIRS on critical systems, including the blood, lungs, central nervous system, and kidneys. It highlights the challenges in diagnosing and managing septic shock in neonates, focusing on the relationship between inflammation and the hemostatic system. Additionally, the paper points out recent advancements, such as the convergent model of coagulation and emerging biomarkers like microRNAs for early detection. Despite this progress, gaps remain in understanding the molecular mechanisms underlying these conditions and in developing effective therapeutic strategies. This highlights the necessity for targeted research to mitigate the morbidity and mortality associated with septic shock in neonates.

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Détails

Titre: Systemic Inflammatory Response Syndrome, Thromboinflammation, and Septic Shock in Fetuses and Neonates
Créateurs - sans rôle: Victoria Bitsadze - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Arina Lazarchuk - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Alexander Vorobev - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Jamilya Khizroeva - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Maria Tretyakova - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Natalia Makatsariya - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Nilufar Gashimova - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Kristina Grigoreva - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Alena Tatarintseva - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Anna Karpova - Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry of Institute of Postgraduate Education of Yaroslavl State Medical University, Yaroslavl State Medical University, Health Ministry of Russian Federation, 5 Revolutsionnaya Str., Yaroslavl 150000, Russia
Aleksei Mostovoi - Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry of Institute of Postgraduate Education of Yaroslavl State Medical University, Yaroslavl State Medical University, Health Ministry of Russian Federation, 5 Revolutsionnaya Str., Yaroslavl 150000, Russia
Marina Zainulina - Department of Obstetrics, Gynecology and Reproductology of Pavlov First Saint Petersburg State Medical University, Pavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation, 6/8 Lev Tolstoy Str., Saint Petersburg 197022, Russia
Daredzhan Kapanadze - Center of Pathology of Pregnancy and Hemostasis «Medlabi», 340112 Tbilisi, Georgia
Armen Blbulyan - Research Center of Maternal and Child Health Protection, 22 Mashtots Avenue, Yerevan 0002, Armenia
Nart Kuneshko - Moscow's Region Odintsovo Maternity Hospital, Odintsovo 143003, Russia
Jean-Christophe Gris - Faculty of Pharmaceutical and Biological Sciences, Montpellier University, 34093 Montpellier, France
Ismail Elalamy - Hôpital américain de paris
Grigoris Gerotziafas - Thrombosis Center, Tenon-Saint Antoine University Hospital, Hôpitaux Universitaires Est Parisien, Assitance Publique Hôpitaix de Paris (AP-HP), 4 Rue de la Chine, 75020 Paris, France
Alexander Makatsariya - Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str 8-2, Moscow 119435, Russia
Détails de publication: International journal of molecular sciences, Vol.26(7), p.3259
Identifiants: 99139168609311
Unité académique: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Langue: English
Type de ressource: Journal article