Abstract
An overview of the work realized by the group regarding the synthesis of fluorinated C-glycosides is described. The various strategies that were investigated allowed the synthesis of CF(2)-glycosides for many carbohydrate series (glucose, mannose and galactose) and for any pseudo-anomeric center configuration (alpha or beta). This work culminated in an efficient preparation of a synthetically useful alpha-CF(2)-galactoside intermediate and its conversion to alpha-CF(2)-galactoconjugates. A synthesis of alpha-CF(2)-galactosylceramide, based on this last methodology, is currently investigated. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.