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Synthesis under moderate pressure of 3-imidazo[1,2- a ]pyridinylidene pyrrol-2-ones
Journal article   Peer reviewed

Synthesis under moderate pressure of 3-imidazo[1,2- a ]pyridinylidene pyrrol-2-ones

Nicolas Masurier, Aurélien Lebrun, Damien Canitrot, Jean-Michel Chezal and Emmanuel Moreau
Tetrahedron Letters, Vol.57(24), pp.2583-2586
06/2016

Abstract

Perkin condensation Lactam Pyrrolinone Pressure
Conversion of 3-imidazo[1,2-a]pyridinylidene furan-2-ones into their pyrrol-2-one analogues was achieved efficiently with high yields, using a solution of ammonium hydroxide under moderate pressure conditions. A NMR study showed that the compounds are mainly isolated as E isomers.
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